中晚期非小细胞肺癌同步放化疗联合DC-CIK细胞生物治疗的疗效观察

Clinical study on concurrent chemo-radiotherapy combined with DC-CIK cells in advanced non small cell lung cancer

目的:通过对同步放化疗联合DC-CIK细胞生物疗法治疗中晚期非小细胞肺癌的临床疗效进行观察,了解该治疗方法在中晚期非小细胞肺癌治疗中的意义及价值。方法:将我院收治的90例患者随机分为单纯同步放化疗组、同步放化疗交替DC-CIK免疫治疗组、同步放化疗序贯DC-CIK免疫治疗组,分别给予相应治疗,观察患者的治疗疗效、免疫水平以及治疗导致的不良反应情况。结果:同步放化疗交替DC-CIK细胞免疫治疗能够提高中晚期非小细胞肺癌患者的完全缓解率、部分缓解率以及临床有效率,但差异不具有统计学意义。同步放化疗交替DC-CIK细胞免疫治疗以及同步放化疗序贯DC-CIK细胞免疫治疗均能够提高中晚期非小细胞肺癌患者的免疫水平。此外,同步放化疗交替DC-CIK细胞免疫治疗能够降低单纯同步放化疗导致的粒细胞水平降低及放射性肺炎的发生率,但可能导致患者发热的发生。结论:同步放化疗交替DC-CIK细胞免疫治疗在中晚期非小细胞肺癌的治疗中较单纯同步放化疗具有优势。

Objective：To understand the significance of concurrent chemo - radiotherapy combined with DC - CIK cells in the treatment of advanced non small cell lung cancer. Methods：A total of 90 patients were randomly divided into three groups ：30 patients in group A received chemo -radiotherapy only ,30 patients in group B received chemo - radiotherapy and alternating DC- CIK immunotherapy,30 patients in group C received chemo- radiotherapy and se- quential DC - CIK immunotherapy. Results： Patients in group B can improve complete remission rate and partial re- mission rate. Patients in group B and the group C improved the level of immunity in advanced non small cell lung cancer （ P 〈 0.05 ）. In addition, the group B can reduce incidence of granulocytopenia and radioactive pneumonia, but may result fever （ P 〈 0.05 ）. Conclusion： Chemo - radiotherapy alternating DC - CIK immunotherapy was better than chemo - radiotherapy alone in advanced non small cell lung cancer.