摘要
目的:比较钠葡萄糖共转运体SGLT1在肝癌组织和癌旁组织的表达,及SGLT1与肝癌TNM分级的相关性。方法:采用SP免疫组化技术,对79例肝癌患者组织芯片进行染色,统计学分析。结果:SGLT1在肝癌中阳性率高于癌旁组织,差异具有统计学意义(P<0.001),并且SGLT1在肝癌中表达程度与肝癌TNM分期具有相关性(P<0.001)。结论:SGLT1在肝癌中表达程度与肝癌TNM分期具有相关性,提示SGLT1在肝癌的发生和发展中有意义,通过对SGLT1介导的肿瘤依赖葡萄糖能量代谢的研究,为肝癌的发展机制研究提供新的理论基础。
Objective ： To detect the expression of sodium/glucose co - transporter 1 （ SGLT1 ） in liver cancer tis- sue and paired adjacent normal tissue, and the relation with the TNM classification of liver cancer. Methods：The ex- pression of SGLT1 in liver cancer tissue and adjacent normal tissue were assayed by immunohistochemical staining. Results：The expression of SGLTI in liver cancer was higher than adjacent normal tissue. And the level of SGLT1 in liver cancer was positively correlated with tumor pathology TNM classification. Conclusion：The SGLT1 protein level is inversely correlated with TNM classfication. Targeting the actions of SGLT1 in cell glucose - dependent energy de- livery may provide an attractive strategy for diagnosis and therapeutic intervention in human hepatocellular carcinoma.
出处
《现代肿瘤医学》
CAS
2015年第3期354-356,共3页
Journal of Modern Oncology
基金
国家自然科学基金(编号:81172287)
关键词
SGLT1
肝癌
免疫组化
SGLT1
hepatocellular carcinoma
immunohistochemical staining
