卵巢颗粒细胞瘤21例诊治分析

Clinical analysis of 21 cases of granulosa cell tumor of ovary

目的:探讨卵巢颗粒细胞瘤的临床病理特征及治疗方法。方法:回顾性分析21例卵巢颗粒细胞瘤的临床资料。结果:全组共21例患者,占同期2025例卵巢肿瘤住院患者的1.04%。成人型19例(90.48%);幼年型2例(9.52%)。FIGO分期Ⅰ期13例,Ⅱ期1例,Ⅲ期6例,Ⅳ期1例。全部行手术治疗,其中行全子宫及双附件切除术9例,行全子宫及单侧附件切除术8例,行剖腹探查腹腔肿瘤切除术4例;其中行全子宫及附件切除术后再次手术3例。13例行辅助化疗;术后随访,5年和10年生存率分别是71.43%和52.38%。结论:卵巢颗粒细胞瘤是一种少见卵巢肿瘤,手术切除是主要治疗方法;临床分期、肿瘤分化程度是影响患者预后的重要因素,术后主张长期随访。

Objective ： To investigate the clinicopathologic features and treatment of granulosa cell tumor of ovary. Methods：Clinical data of 21 cases of granulosa cell tumor of ovary were retrospectively analyzed. Results ：There were 21 cases of granulosa cell tumor of ovary from January 2001 to January 2013 in our hospital, accounted for 1.04% of the all ovary tumors at the same period in hospital. There were 19 cases of adult type and 2 cases of juvenile type. Ac- cording to 1986 FIGO classification system,patients in stage Ⅰ, Ⅱ , Ⅲ and Ⅳ were 13,1,6 and 1 cases,respectively. All cases were operated, including 9 cases hysterectomy and bilateral salpingo -oophorectomy,8 cases of hysterectomy and unilateral salpingo - oophorectomy ,4 cases of exploratory laparotomy abdominal tumor resection, including 3 cases of tumor debulking for recurrence. 13 cases were performed adjuvent chemical therapy. As postoperative follow - up data showed,5 - year survival rate and 10 - year survival rates were 71.43 % and 52.38 % , respectively. Conclusion： Granulosa cell tumor of the ovary is an uncommon neoplasm. Surgery management is the first suggested treatment method. Stage of the disease and tumor cell differentiation have been shown to affect survival of patients. A prolonged post- therapeutic follow- up is necessary.