期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

维生素D受体基因多态性与1型糖尿病易感性的Meta分析 被引量：7

Associations between polymorphisms of Vitamin D receptor gene and type 1 diabetes susceptibility:A meta-analysis
原文传递
导出
摘要 目的探讨维生素D受体（VDR）基因多态性与T1DM易感性的关系。方法通过检索PubMed、Web of Science、WanFang等数据库获得相关文献,计算相关基因位点的OR值和95%CI。结果共纳入文献28条。分析结果发现,BsmI和ApaI多态性是亚洲T1DM人群的易感基因[B vs b：OR（95%CI）=1.53（1.06-2.20）,P=0.024;AAvs aa：OR（95%CI）=1.60（1.06-2.40）,P=0.023]。结论 BsmI和ApaI多态性可能是亚洲T1DM人群的易感基因。 Objective To explore the associations between polymorphisms of Vitamin D receptor gene and type 1 diabetes susceptibility. Methods Literatures were retrieved from PubMed,Web of Science and WanFang databases,etc.Pooled odds ratios（ORs）with 95% confidence intervals（CIs）were calculated using a random effect model. Results A total of 28 literatures were included.The result of analysis showed that BsmI and ApaI polymorphism were the susceptibility gene for T1DM in Asian populations[B vs b;OR（95%CI）=1.53（1.06-2.20）,P=0.024;AAvs aa：OR（95%CI）=1.60（1.06-2.40）,P=0.023]. Conclusion The BsmI and ApaI polymorphism may be susceptibility gene in Asians populations with T1DM.
作者 王国凤 徐宽枫 杨涛
机构地区 江苏省连云港市第一人民医院内分泌科 南京医科大学第一附属医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2015年第2期110-114,共5页 Chinese Journal of Diabetes
关键词 维生素D受体 基因多态性 糖尿病 1型 META分析 Vitamin D receptor（VDR） Genetic polymorphism Diabetes mellitus type 1 Meta-analysis
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献4

二级参考文献25

  • 1Stumpf WE, Sar M, Reid FA, et al. Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science, 1979, 206:1188-1190.
  • 2Marti G, Audi L, Esteban C, et al. Association of vitamin D receptor gene polymorphism with type 1 diabetes mellitus in two Spanish populations. Medicina Clinica(Barc) ,2004,123:286-290.
  • 3Taverna MJ, Selam JL, Slama G. Association between a protein polymorphism in the start codon of the vitamian D receptor gene and severe diabetic retinopathy in C-peptide-negative type 1 diabetes. J Clin Endocrinol Metab, 2005, 90:4803-4808.
  • 4Morrison NA, Qi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles. Nature, 1994, 367: 216-217.
  • 5Ban Y, Taniyama M, Yanagawa T, et al. Vitamin D receptor initiation codon polymorphism influences genetic susceptibility to type 1 diabetes mellitus in the Japanese population. BMC Med Genet, 2001, 2:7.
  • 6Gyorffy B, Vasarhelyi B, Krikovszky D, et al. Gender-specific association of vitamin D receptor polymorphism combinations with type 1 diabetes mellitus. Eur J Endocrinol, 2002, 147: 803-808.
  • 7Turpeinen H, Hermann R, Vaara S, et al. Vitamin D receptor polymorphisms : no association with type 1 diabetes in the Finnish population. Eur J Endocrinol, 2003, 149: 591-596.
  • 8Morrison NA, Yeoman R, Kelly PJ, et al.Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin. Proc Natl Acad Sci U S A 1992;89 (15):6665-9
  • 9Garnero P, Borel O, Sornay-Rendu E, et al. Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. J Bone Miner Res 1995;10(9):1283-8
  • 10Riggs BL, Nguyen TV,Melton LJ 3rd,et al.The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 1995;10(6):991-6

共引文献32

同被引文献71

  • 1刘炳曼,司晓芸.维生素D受体(VDR)BsmⅠ基因多态性与慢性肾脏病的研究进展[J].武汉大学学报（医学版）,2020(4):684-688. 被引量：3
  • 2Yang CY, Leung PS, Adamopoulos IE, et al. The implication of vitamin D and autoimmunity: a comprehensive review [ J ]. Clin Rev Allergy Immunol, 2013, 45(2) : 217-226.
  • 3Gonz(flez-Molero I, Rojo-Martfnez G, Morcillo S, et al. Vitamin D and incidence of diabetes : a prospective cohort study[ J]. Clin Nutr, 2011, 31(4):571-573.
  • 4Nsiah-Kumi PA, Erickson JM, Beals JL, et al. Vitamin D insuffi- ciency is associated with diabetes risk in Native American chil- dr~n[.l].Clin Pediatr (Phila) .2012,51(2) : 146-153.
  • 5Takiishi T, Gysemans C, Bouillon R, et al. Vitamin D and diabe- tes [ J ]. Rheum Dis Clin North Am, 2012,38 ( 1 ) : 179-206.
  • 6Choi HS, Kim KA, Lira CY, et al. Low serum vitamin D is associ- ated with high risk of diabetes in Korean adults[J]. J Nutr,2011, 141(8) :1524-1528.
  • 7Hurskainen AR, Virtanen JK, Tuomainen TP, et al. Association of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland [ J ]. Diabetes Metab Res Rev, 2012, 28(5) : 418-423.
  • 8Mitri J, Dawson-Hughes B, Hu FB, et al. Effects of vitamin D and calcium supplementation on pancreatic ~ cell function, insu- lin sensitivity, and glycemia in adults at high risk of diabetes : theCalcium and Vitamin D for Diabetes Mellitus(CaDDM) random- ized controlled trial[J]. Am J Clin Nutr, 2011, 94(2) : 486- 494.
  • 9Shab-Bidar S, Neyestani TR, Djazayery A. Improvement of vita- min D status resulted in amelioration of biomarkers of systemic in- flammation in the subjects with type 2 diabetes [ J ]. Diabetes Metab Res Rev, 2012, 28(5) :424-430.
  • 10Lang PO, Samaras D, Samaras N, et al. Does vitamin D defi- ciency contribute to further impinge the state of vulnerability to infections of aging and aged adults[J]. Eur Geriatr Med, 2013, 4(1) :59-65.

引证文献7

二级引证文献46

中国糖尿病杂志
2015年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部