新诊断2型糖尿病患者血清尿酸水平的影响因素分析

Influencing factors analysis of serum uric acid levels in newly diagnosed type 2 diabetic patients

目的探讨新诊断T2DM患者血清尿酸(SUA)水平的影响因素。方法选取新诊断T2DM患者490例,根据SUA水平分为合并高尿酸血症(T2DM+HUA)组67例和单纯T2DM组(T2DM组)323例。测定临床及相关生化指标,分析SUA升高的影响因素。结果 (1)新诊断T2DM患者高尿酸血症的患病率为13.67%(67/490),男性高于女性[9.80%(48/490)vs 3.88%(19/490),P=0.012];(2)T2DM+HUA组BMI、WC、谷丙转氨酶(ALT)、谷草转氨酶(AST)、TG、C-P、胰岛素抵抗指数(HOMA-IR)均高于T2DM组,年龄、HbA1c、HDL-C、ISI低于T2DM组(P<0.05);(3)多元线性回归分析显示,年龄、女性及HDL-C为SUA的保护性因素,2hC-P为SUA水平增高的危险因素。年龄是男性HUA的保护性因素,2hC-P为SUA水平增高的危险因素。HDL-C和ISI为女性HUA的保护性因素,脱酸脱氢酶(LDH)和2hC-P是女性HUA发生的危险因素。结论新诊断T2DM患者SUA水平受年龄、性别、肝功能、HDL-C及IS影响。

Objective To explore the influencing factors for serum uric acid（SUA）levels in newly diagnosed type 2 diabetic patients（T2DM）. Methods 490 cases of newly diagnosed T2DM were divided into groups：T2DM with high serum uric acid（T2DM＋HUA,n=67）and T2DM without high uric acid group（T2DM,n=323）.The clinical and biochemical data were measured and the influencing factors of HUA were analyzed. Results（1）Prevalence rates of HUA in newly diagnosed T2 DM were 13.67%（67/490）,and the prevalence rates of HUA was higher in male than in female[9.80%（48/490）vs3.88%（19/490）,P=0.012];（2）BMI,WC,alanine aminotransferase（ALT）,aspartate transaminase（AST）,TG,C-P,HOMA-IR were higher and age,HbA1 c,HDL-C and HOMA-IS were lower in T2DM＋HUA group than in T2DM group（P〈0.05）;（3）Multivariable linear regression analyses showed that age,female and HDL-C were the protective factors for HUA,and independent risk factor for high SUA level was 2hC-P.Age was the protective factor for male patients with HUA,and 2hC-P was risk factor for high SUA level.HDL-C and HOMA-IR were the protective factors for female,and LDH and 2hC-P were risk factors for high SUA level. Conclusion Serum uric acid levels in newly diagnosed T2 DM were affected by age,gender,liver function,HDL-C,and IS.