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转录因子NEF2相关因子2在糖尿病肾病中的研究进展 被引量：4

Research progress on the role of transcription factor Nrf2 in diabetic nephropathy
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摘要 DN是糖尿病的主要并发症之一,也是糖尿病患者死亡的重要原因。患者体内持续的高血糖会诱导产生过多的活性氧簇(ROS),加剧DN的进展。NFE2相关因子2(Nrf2)是细胞内维持氧化应激(OS)平衡的重要转录因子,在缓解糖尿病诱导的OS或损伤中发挥重要作用。 Oxidative stress and inflammation are two main factors in the progress of diabetic nephropathy（DN）and its complications.NF-E2p45-related factor（Nrf2）is a crucial transcriptional factor which manipulates downstream genes that encode some antioxidant enzymes and phase Ⅱ detoxifying enzymes,to maintain the redox homeostasis and cellular detoxification response.Therefore,more and more researchers are focusing on the role of Nrf2 in DN.In this review,the detailed role of Nrf2 in DN will be discussed.Hopefully,our work can epitomize recent research progress and provide novel clues for diabetic nephropathy prevention and treatment.
作者 高攀 张农
机构地区 复旦大学基础医学院病理学系
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2015年第2期182-184,共3页 Chinese Journal of Diabetes
基金 国家自然科学基金(81270810)
关键词 NEF2相关因子2 糖尿病肾病 活性氧簇 激活剂 NE-F2-related factor 2（Nrf2） Diabetic nephropathy（DN） Reactive oxygen species（ROS） Activators
分类号 R587.2 [医药卫生—内分泌]
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参考文献23

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二级参考文献25

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共引文献9

同被引文献49

  • 1罗冬平,陈孟珂,宁小元,徐家云.沉默信息调节蛋白1在糖尿病性肾病发病机制中的作用研究进展[J].军事医学,2020(8):629-633. 被引量：2
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引证文献4

二级引证文献47

中国糖尿病杂志
2015年 第2期

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