西吡氯铵含漱液预防颌骨囊肿患者术后感染临床效果观察

Observation of clinical effect of Cetylpyridnium Chloride Gargle for the prevention of postoperative infections of jaw cyst operation

目的探讨西吡氯铵含漱液预防颌骨囊肿患者术后感染临床效果,为临床预防与治疗提供依据。方法选择医院2011年1月-2013年7月收治的颌骨囊肿患者968例,将其随机分为对照组510例、观察组458例,对照组患者颌骨囊肿术后采用常规治疗,观察组患者在对照组治疗基础上应用西吡氯铵含漱液,评估两组患者术后感染率,肿胀、疼痛评分及治愈平均时间、菌斑指数(PLI),并观察患者不良反应发生率。结果观察组患者感染7例,感染率为1.53%,对照组感染31例,感染率6.08%,差异有统计学意义(P<0.05);肿胀、疼痛、PLI评分观察组患者分别为(0.84±0.41)、(1.53±0.47)、(0.79±0.33)分,均低于对照组的(1.24±0.53)、(2.11±0.90)、(1.30±0.49)分,差异有统计学意义(P<0.05);两组患者不良反应评分比较,差异无统计学意义;平均病愈时间观察组为(52.40±4.09)d,少于对照组(58.62±3.17)d,差异有统计学意义(P<0.05)。结论应用西吡氯铵含漱液预防颌骨囊肿术后感染具有较好的临床效果,能降低感染率,具有良好的安全性,值得临床推广应用。

OBJECTIVE To explore the clinical effect of Cetylpyridnium Chloride Gargle for the prevention of postoperative infection of jaw cyst operation,and provide basis for clinical prevention and treatment.METHODS Totally 968 patients with jaw cysts in the hospital from Jan.2011 to Jul.2013 were selected and were randomly divided into the control group of 510 cases and the observation group of 458 cases.The control group received conventional treatment after jaw cyst operation,while the observation group received Cetylpyridnium Chloride Gargle based on the treatment of the control group.The main evaluation indexes were postoperative infection rate,swelling,pain score and average cure time,plaque index（PLI）and incidence rate of adverse reactions of two groups.RESULTS Infection occurred in 7cases（the infection rate 1.53%）in the observation group and 31cases（6.08%）in the control group,the difference was significant（P〈0.05）.The scores of swelling,pain and PLI were（0.84±0.41）points,（1.53 ± 0.47）points and（0.79±0.33）pints in the observation group,lower than（1.24±0.53）points,（2.11 ± 0.90）points and（1.30±0.49）points in the control group,the difference was significant（P〈0.05）.There was no significant difference in the scores of adverse reactions between two groups（P 〉0.05）.The average cure time was（52.40±4.09）d in the observation group,less than（58.62 ± 3.17）d in the control group,the difference was significant（P〈0.05）.CONCLUSION Cetylpyridnium Chloride Gargle had better clinical effect for the prevention of postoperative infection of jaw cyst operation,which could reduce the infection rate with good safety and was worthy of clinical application.