地塞米松与布地奈德联合治疗急性感染性喉炎患儿的临床效果研究

Observation of effect of dexamethasone combined with budesonide applied in pediatric acute infectious laryngitis treatment

目的研究地塞米松与布地奈德联合治疗急性感染性喉炎患儿的临床效果。方法选择2011年9月-2014年9月耳鼻喉科收治的急性感染性喉炎患儿96例,按随机数字表法分为对照组和观察组各48例,对照组患儿给予抗菌、抗病毒、止咳、退热等综合治疗,观察组在对照组基础上加用地塞米松静脉滴注及布地奈德雾化吸入;治疗24h后比较两组患儿的疗效。结果观察组患儿临床症状消失时间均短于对照组,差异有统计学意义(P<0.05),观察组患儿总住院时间为(6.1±0.7)d,短于对照组的(10.8±2.4)d,差异有统计学意义(P<0.05);治疗总有效率观察组为100.0%、对照组为91.7%,观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);患儿治疗后不良反应发生率观察组为6.3%、对照组为8.4%,两组比较差异无统计学意义。结论采用地塞米松与布地奈德联合应用治疗合并急性感染性喉炎患儿效果确切,且安全性好,值得临床推广。

OBJECTIVE To observe the effect of dexamethasone combined with budesonide applied in pediatric acute infectious laryngitis treatment.METHODS Totally 96 cases of children with acute infectious laryngitis treated in otolaryngological department from Sep.2011 to Sep.2014 were selected and divided into control group and observation group by random table,with 48 cases in each group.Complex treatment such as antibiotic treatment,antiviral treatment,relieving cough,antipyretic and etc was given in control group.Dexamethasone and budesonide were added in observation group.The curative effect in the two groups was compared in 24 hours after the treatment.RESULTS The time of symptoms disappeared in observation group were shorter than that in control group.The differences were significant（P〈0.05）.The mean time of hospitalization in observation group was（6.1±0.7）days,and（10.8±2.4）days in observation group,the time in observation group was shorter than that in control group.The differences were significant（P〈0.05）.The total effective rate in observation group was 100.0%,while 91.7%in control group.The effective rate in observation group was higher than that in control group.The differences were significant（P〈0.05）.The incidence rate of adverse reaction in observation group was 6.3%,while 8.4%in control group,and there was no significant difference between the two groups.CONCLUSION The effect of dexamethasone combined with budesonide applied in pediatric acute infectious laryngitis with laryngemphraxis was good and safe.It was worthy of clinical application.