奥硝唑治疗厌氧菌性盆腔感染的临床研究

Clinical study of ornidazole in treating pelvic infections due to anaerobion

目的探讨奥硝唑治疗厌氧菌引起的盆腔感染临床效果及安全性。方法选取2012年4月-2013年11月厌氧菌性盆腔感染患者160例,随机分为普通组和治疗组,每组各80例,普通组使用替硝唑氯化钠注射液静脉滴注,每次0.5g,每天两次,维持治疗7d,治疗组使用奥硝唑氯化钠注射液静脉滴注,用法同普通组,治疗后对比两组患者治疗效果、细菌清除率及不良反应发生率。结果普通组治愈65例,治愈率81.25%,治疗组治愈66例,治愈率82.50%,两组临床效果相近,差异无统计学意义;细菌清除率普通组为95.35%、治疗组为97.22%,两组临床效果相近,对比差异无统计学意义;治疗后不良反应发生率治疗组为3.75%、普通组为27.50%,两组对比差异有统计学意义(χ2=11.347,P<0.05)。结论针对厌氧菌引起的盆腔感染患者使用奥硝唑氯化钠注射液治疗临床效果显著确切,且安全性高,值得临床推广应用。

OBJECTIVE To investigate the clinical effect and safety of orinidazole in the treatment of pelvic infections caused by anaerobic bacteria. METHODS From Apr. 2012 to Nov. 2013, 160 patients with pelvic infections were selected and randomly divided into common group and treatment group, with 80 cases for each. The common group was treated with intravenous drip of tinidazole sodium chloride injection, 0. 5 g/times, 2 times/d, 7 days were maintained for treatment. The treatment group used ornidazole sodium chloride intravenous drip, the usage was the same as the common group. The therapeutic effect, the bacterial clearance rate and the rate of adverse reactions were compared between the two groups after treatments. RESULTS A total of 65 cases were cured in the common group, the cure rate was 81.25%, and in the treatment group, 66 cases were cured, the cure rate was 82.50%. The clinical effects of the two groups were very close, so the differences were no significance. The bacterial clearance rate in the common group and the treatment group was 95.35% and 97.22% respectively. The similar clinical effect had no significant difference. The occurrence rate of adverse reactions was 3.75% in the treatment group and was 27. 50% in the common group. The differences had significance （X2 = 11. 347, P〈0.05）. CONCLUSION Ornidazole sodium chloride injection has remarkable and clear clinical effect for patients with pelvic infections caused by anaerobic bacteria and it is of high safety, which is worthy to be popularized and applied in clinic.