两亲性多肽自组装及其应用

Self-assembly of Peptide Amphiphiles and Their Applications

两亲性多肽分子具有类似天然磷脂分子的两亲特性、丰富的分子结构、独特新颖的组装体结构以及特殊的生物学功能,是多肽自组装研究的热点领域.本文总结了近年来关于两亲性多肽自组装研究及应用的进展,介绍了几种常见的两亲性多肽,并进一步阐述其分子结构特征、组装行为和机理、组装体结构和功能以及在纳米技术和生物医学领域中的应用.

Due to good biocompatibility, straight forward chemical modification and inherent molecular recog-nition, peptides have been very attractive biological building blocks for self-assembly. Amphiphilic peptides are of special interesting with the advantages of abundant molecular structures, unique structures of assemblies and special biological functions. In this work, the recent progress in the study and application of the self-assembly of amphiphilic peptides was reviewed. Several kinds of amphiphilic peptides were introduced. More-over, the molecular structures of amphiphilic peptides, the behavior and mechanism of self-assembly, the structure and property of assemblies and their applications in nanotechnology and biomedical field were also demonstrated in detail.