白苞蒿的化学成分研究(Ⅲ)

Chemical Constituents from the Aerial Parts of Artemisia lactiflora( Ⅲ)

目的 研究白苞蒿的化学成分。方法 采用多种色谱方法,对白苞蒿的体积分数95%乙醇提取物的石油醚部位进行分离纯化,根据波谱学数据鉴定化合物的结构。结果 得到10个化合物,分别为去氢吐叶醇（1）、3-羟基-1-（4-羟基-3,5-二甲氧基苯基）-1-丙酮（2）、chrysindin D（3）、山茶皂苷元A（4）、4′-O-甲基高山金莲花素（5）、5-羟基-3′,4′,6,7,8-五甲氧基黄酮（6）、狭叶墨西哥蒿素（7）、3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one（8）、假虎刺酮（9）、（E）-3β,4α-二羟基-2-（2′,4′-己二炔亚基）-1,6-二氧杂螺[4,5]癸烷（10）。结论 化合物1～5为首次从蒿属中分离得到,化合物6~10为从该植物中首次分离得到。

OBJECTIVE To investigate the chemical constituents from the aerial parts of Artemisia lactiflora. METHODS The chemical constituents were isolated by silica gel and Sephadex LH -20 methods, and the structures were identified by NMR and MS. RESULTS Ten compounds were isolated and identified as follows： dehydrovomifoliol（ 1 ）, 3-hydroxy-1-（4-hydroxy-3, 5-dimethoxy- phenyl ） - 1 -propanone （ 2 ）, chrysindin D （ 3 ）, camelliagenin A （ 4 ）, 4′-O-methylalpinumisoflavone （ 5 ）, 5-hydroxy-3′,4′, 6,7,8-pentamethoxyflavone （ 6 ）, armexifolin （ 7 ）, 3/3-hydroxy-5α, 6α-epoxy-7-megastigmen-9-one （ 8 ）, carissone （ 9 ）, and （E） -3β,4α-dihydroxyl- 2-（2′,4′-hexadiynylidene）-1 ,6-dioxaspiro[4,5]decane（10）. CONCLUSION Compounds 1 -5 are obtained from genus Artemisia for the first time and 6 - 10 are isolated from this plant for the first time.