支气管哮喘-慢性阻塞性肺疾病重叠综合征265例

Asthma COPD overlap syndrome: retrospective analysis of 265 cases

目的:研究支气管哮喘-慢性阻塞性肺疾病重叠综合征(asthma COPD overlap syndrome,A COS)的诊治情况。方法 :对265例ACOS及850例单纯哮喘患者从一般情况、危险因素、临床特点、1年内急性加重住院次数及治疗方案方面进行统计分析。结果:ACOS的危险因素为吸烟、FEV1<50%预计值、低收入。ACOS的临床表现均较单纯哮喘组差,1年内急性加重住院次数(≥2次)也增高,85.7%患者应用ICS联合LABA/LAMA治疗。结论:ACOS较单纯哮喘患者病情重,急性加重频繁。吸烟、肺功能差、收入低是其危险因素。ICS联合LABA/LAMA治疗不充分,有待加强。

Objective To investigate diagnosis and treatment of Asthma COPD overlap syndrome （ACOS）. Methods Clinical data of the general situation, risk factors, clinical manifestations, frequent exacerbation and hospitalization within one year, treatment between ACOS patients （n = 265） and simple asthma （n = 850） were analysed. Results Smoking, FEV1 〈 50% predicted and low income were risk factors for ACOS. Compared with simple asthma patients, the clinical manifestations of ACOS were worse, and the frequency of exacerbation and hospitalization within one year （twice and above）were higher. ICS combined with LABA/LAMA were applied in 85.7% of ACOS patients. Conclusions Compared with simple asthma, ACOS has the characteristics of high severi- ty, frequent exacerbation. Smoking, poor lung function and low income are the risk factors of ACOS. The applica- tion of ICS combined with LABA/LAMA therapy was inadequate in ACOS patients, which is need to be strengthened.