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叉毛蓬化学成分的体外抗菌及抗氧化活性研究(英文) 被引量:4

Antibacterial and Antioxidant Properties of Compounds Extracted from Petrosimonia sibirica L.
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摘要 从叉毛蓬全株首次分离出4-羟基苯乙酮(1)、紫丁香酸(2)、金圣草黄素(3)、香草酸(4)、4-羟基-3-甲基苯乙醇(5)、N-[2-(3,4-二羟基苯基)-2-羟基乙基]-3-(4-甲氧基苯基)丙-2-稀酰胺(6)和异鼠李素-3-O-芸香糖苷(7)7个化合物。通过MTT法测定这7个化合物的体外抗菌活性,结果表明多数化合物有较强的抗菌活性,其中化合物2对枯草芽孢杆菌,化合物5对大肠杆菌,化合物7对番茄疮痂病菌和番茄早疫病菌的抑制作用均强于阳性对照硫酸链霉素对同种菌的抑制。用DPPH和FRAP两种方法测定了化合物的抗氧化活性,结果表明在DPPH方法中化合物6的抗氧化活性最好,IC50值为0.2452 mg/m L,在FRAP方法中化合物5有最好的抗氧化活性,FRAP值为9.402 mmol/g,强于阳性对照抗坏血酸。 4-Hydroxyacetopbenone (1), syrlngic acid (2), chrysoerlol (3), vanltllc acid (4) ,4-hydroxy-3-methoxy ben- zene ethanol (5) ,N-[2-(3,4-dihydroxyphenyl)-2-hydroxycthyl]-3-(4-methoxyphenyl) prop-2-enamide (6) and isorh- amnetln-3-O-rutlnoside (7) were isolated from Petrosimonia sibirica L for the first time. In v/tro antibacterial activity of these compounds was evaluated by MTF assay. The results revealed that most of these compounds exhibited significant activity. The antimicrobial activities of compound 2 against Bacillus subtilis, of compound $ against Escherichia coli, and of compound 7 against Xanthomonas vesicatoria and Alternaria solani,were found to be stronger than those of the positive control,streptomycin sulfate. The antioxidant potential was evaluated by DPPH and FRAP methods. The results demon- strated that compound 6 was the most effective in DPPH method, with ICso value of 0. 2452 mg/mL. Compound 5 was rel- atively active and showed potent antioxidant effect compared to standard ascorbie acid in FRAP assay,with FRAP value of 9.402 mmol/g.
出处 《天然产物研究与开发》 CAS CSCD 北大核心 2015年第2期251-254,共4页 Natural Product Research and Development
基金 financially supported by Natural Science Foundation of China(NSFC,No.21162023) Bingtuan International Cooperation Projects(No.2011BC003)
关键词 叉毛蓬 抗菌 抗氧化 MTT DPPH FRAP Petrosimonia sibirica L. antibacterial antioxidant MTr DPPH FRAP
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