天然抗补体活性物质研究进展

Review on the Research and Development of Anti-complementary Agents from Natural Products

补体系统的非正常激活可引起人体的多种疾病,包括类风湿性关节炎和老年性痴呆等,但目前还没有较好的抗补体制剂。化学合成的抗补体制剂成本高、选择性差、并能产生多种副作用,天然产物来源的抗补体活性成分引起了国内外学者的普遍关注。迄今为止,已经从动植物及微生物中分离出多种具有抗补体活性的物质,包括多糖、黄酮、甾体、皂苷、萜类、生物碱等。本文对近年来天然产物中具有抗补体活性的成分进行了综述,由于微生物易于培养及基因工程改良,而且产品质量容易控制,来自微生物的抗补体活性物质值得关注。

The improper activation of complement system may lead to a variety of diseases, such as rheumatoid arthritis and Alzheimer＇ s disease. Anti-complementary agents prepared by chemical synthesis have the limitations such as high cost,low selectivity and unwanted side effects. Therefore, natural products as anti-complementary agents have received worldwide attention. Up to now, a number of anti-complementary natural products have been isolated from animals, plants and microorganisms, which include polyseccharides, flavones, terpenes, steroids, saponins and alkaloids. In this review, the anti-complementary constituents newly discovered during the recent years were summarized. The prospect on the de- velopment of anti-complementary agents derived from natural products, especially from microorganisms, were also dis- cussed. Due to the ease of cultivation and genetic manipulation, as well as convenience in quality control, anti-comple- mentary compounds from microorganisms deserve more attention.