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冻干血小板的制备及其应用的研究进展 被引量:3

Review of development in preparation and application of lyophilized platelets
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摘要 研究血小板冻干保存的重要目的是实现血小板的常温下长期保存,可用于静脉输注,并能将其制备成生理性止血药和促创面愈合的药物,用于战争、自然灾害、突发事件和特别偏远地区伤病员的救治。国内外研究结果表明:血小板冻干是一个特别有价值的重要研究领域,研究制备出合格的冻干血小板有极大的可能性,但目前仍有许多问题没有得到很好的解决,仍需要政府和同道们进行高度重视和深入研究,造福于伤病员的健康。 To achieve the aim of long-term preservation of platelet at room temperature is one of the important purposes of the platelet freeze-drying research. In this way, freeze-dried platelets could be used for intravenous infusion. Furthermore, freeze-dried platelets could be developed as hemostatic or accelerating wound healing drugs for war, natural disasters, emer- gencies and special treatment of patients in remote areas. Both the domestic and foreign research show that the platelet freeze- drying is a particularly valuable and important research field. It is a real possibility to develop qualified lyophilized platelets. ttowever, at present there are still many problems to be resolved. It still needs government and fellow friends to pay more at- tention and carry out in-depth research for the benefit of patients.
出处 《中国输血杂志》 CAS 北大核心 2015年第1期1-4,共4页 Chinese Journal of Blood Transfusion
基金 国家科技重大专项课题(2011ZXJ09104-07C)
关键词 血小板 冻干保存 海藻糖 止血 创面修复 platelet freeze-drying preservation trehalose hemostasis wound repair
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参考文献34

  • 1Crovetti G,Martinelli G,Issi M,et al.Platelet gel for healing cutaneous chronic wounds.Transfus Apher Sci,2004,30(2):145-151.
  • 2Tang YQ,Yeaman MR,Selsted ME.Antimicrobial peptides from human platelets.Infect Immun,2002,70(12):524-6533.
  • 3Hoffmeister KM,Felbinger TW,Falet H,et al.The clearance mechanism of chilledblood platelets.Cell,2003,112(1):87-97.
  • 4Klein E,Farber S,Djerassi I,et al.The preparation and clinical administration of lyophilized platelet material to children with acute leukemia and aplasticanemia.J Pediatr,1956,49(5):517-522.
  • 5Wolkers WF,Walker NJ,Tablin F,et al.Human platelets loaded with trehalose survive freeze-drying.Cryobiology,2001,42(2):79-87.
  • 6卢发强,刘景汉,欧阳锡林,孙桂香.人血小板冻干前预处理技术的实验研究[J].中国医师杂志,2006,8(5):599-601. 被引量:8
  • 7张绍志,朱发明,范菊莉,吴丹红,陈光明.超声波用于海藻糖载入血小板[J].细胞生物学杂志,2008,30(1):121-124. 被引量:2
  • 8王捷熙,杨超,郭永,等.小分子糖类物质在血小板的冷冻干燥保存中的生物保护作用的初步研究.武汉:第五届全国低温生物学及器械学术大会.2006.
  • 9Wolkers WF,Walker NJ,Tamari Y,et al.Towards a clinical application of freeze-dried human platelets.Cell Preserv Technol,2002,1(3):175-188.
  • 10周俊,刘景汉,邢颜超,王冬梅.PGE_1对血小板的体外激活抑制作用[J].临床输血与检验,2007,9(2):101-105. 被引量:8

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