人纤维蛋白溶酶原和人纤维蛋白溶酶的研制进展

Progress in the research on plasminogen and plasmin

人纤维蛋白溶酶原是人纤维蛋白溶酶的前体物质,没有活性。在正常人体内,人纤维蛋白溶酶原通过纤维蛋白溶酶原激活因子激活转变成有活性的人纤维蛋白溶酶。有研究表明人纤维蛋白溶酶原和人纤维蛋白溶酶在临床治疗中有广阔的应用前景,但是这2种制品在国内外都没有相应的商业化产品可供临床使用。科学技术的发展使大规模生产、使用人纤维蛋白溶酶原和人纤维蛋白溶酶成为可能。我们就人纤维蛋白溶酶原和人纤维蛋白溶酶的研究进展,以及从人血浆中制备人纤维蛋白溶酶原的方法作简要综述。

Plasminogen is an inactive precursor of plasmin whose role is to degrade fibrins. Normally, plasminogen can transform into plasmin after being activated by plasminogen activator in vivo. Current study suggests that plasminogen and plasmin have extensive application prospects in clinical therapy, but both products are not sold commercially for clinical use in domestic and international markets. With the development of the technology and science, it has become possible to make large-scale production and extend the application of plasminogen or plasmin. Based on the research progress on plasminogen and plasmin, this article briefly summarizes the methods to manufacture plasminogen and plasmin from human plasma.