我院妇科门诊女性生殖道真菌感染的病原学特点及药敏分析

Analysis of Etiological Characteristics and Drug Sensitivity of Fungal Infection in Female Genital Tract of Gynecological Outpatient in Our Hospital

目的:了解贵阳地区女性生殖道真菌感染的病原学特点及对抗真菌药的耐药性,为临床治疗提供参考。方法:采用科玛嘉念珠菌显色培养基及ATB Expression自动细菌鉴定仪进行病原菌的鉴定,用ATB Fungus 3药敏试验卡进行体外药敏试验。结果:我院妇科门诊498例女性生殖道真菌感染率为34.9%,感染病原菌以白色念珠菌及光滑念珠菌所占比例较高,分别占52.3%、24.4%。病原菌对5种抗真菌药均存在不同程度的耐药性,以两性霉素B的耐药率最低,伊曲康唑耐药率最高。结论:该地区女性生殖道真菌感染病原菌构成多样,不同病原菌对抗真菌药的耐药性相差较大。临床应加强女性生殖道真菌感染的病原学和耐药性监测,根据药敏试验结果合理使用抗真菌药。

OBJECTIVE： To understand the etiological characteristics and drug sensitivity of fungal infection in female genital tract of Guiyang region, and to provide reference for clinical treatment. METHODS： CHROMagar candida chromogenic medium and ATB bacterial identification analyzer were used to identify the pathogenic fungi, and ATB Fungus 3 drug sensitive card was used for drug sensitivity test in vitro. RESULTS： The rate of genital fungal infection was 34.9% in 498 cases of female patients of gynecological outpatient in our hospital; Candida albicans and Candida glabrata had the highest proportion of pathogenic fungal in- fection, which accounted for 52.3%, 24.4%. Pathogenic fungus was resistant to 5 antifungal drugs at different degrees; drug resis- tance of amphotericin B was the lowest, and itraconazole was the highest. CONCLUSIONS： The pathogenic bacteria of female geni- tal tract fungal infection has composition diversity in the orea; drug resistance of different pathogenic fungus to antifungal drugs is different greatly; the monitoring of etiology of female genital tract fungal infection and drug resistance should be strengthened in clinic, and antifungal drugs should be used rationally according to the results of drug sensitivity test.