摘要
目的:了解我院抗菌药物所致药品不良反应(ADR)发生的特点,为临床合理使用抗菌药物提供参考。方法:对我院2011-2013年上报的159例抗菌药物致ADR报告,按患者的性别及年龄、科室分布、给药途径、涉及药品种类、联合用药情况、ADR累及器官/系统及临床表现等进行回顾性统计、分析。结果:0~10岁患儿和〉60岁老年患者ADR发生率最高,分别占23.90%、34.59%;抗菌药物静脉给药途径ADR发生率最高,占86.16%;头孢菌素类药物发生的ADR最多,占30.82%;联合用药致ADR高达31.45%;抗菌药物所致ADR主要累及皮肤及其附件损害,占32.08%。结论:医疗机构应加强抗菌药物ADR的报告和监测工作,确保患者用药安全。
OBJECTIVE: To investigate the characteristics of antibiotics-induced ADR in our hospital, in order to promote the rational use of antibiotics in the clinic. METHODS: 159 cases of antibiotics-induced ADR reported in our hospital during 2011-2013 were analyzed retrospectively in respects of patient' s gender and age, department distribution, route of administration, drug category, drug combination, clinical manifestations, etc. RESULTS : The patients aged 0-10 years and 〉 60 years old took up the highest proportion accounting for 23.90%, 34.59%, respectively. ADR induced by intravenous route of administration had the highest incidence, accounting for 86.16% ; cephalosporins-induced ADR was the most, accounting for 30.82% ; drug combination-induced ADR was up to 31.45% ; lesion of skin and its appendents was main antibiotics-induced ADR, accounting for 32.07%. CONCLUSIONS: The antibiotics-induced ADR monitoring and report should be strengthened in medical institutions so as to ensure the safety of drug use.
出处
《中国药房》
CAS
北大核心
2015年第5期639-641,共3页
China Pharmacy