单唾液酸四己糖神经节苷脂联合伐昔洛韦治疗老年带状疱疹的临床观察

Clinical Observation of Ganglioside Combined with Valaciclovir in the Treatment of Elderly Herpes Zoster

目的:观察单唾液酸四己糖神经节苷脂联合伐昔洛韦治疗老年带状疱疹的疗效和安全性。方法:90例老年带状疱疹患者随机分为治疗组(47例)与对照组(43例)。对照组口服伐昔洛韦片1 g,bid,连用1周;维生素B1片10 mg,tid+甲钴胺胶囊0.5mg,tid,连用2周。治疗组在对照组用药基础上加用单唾液酸四己糖神经节苷脂注射液20 mg,加入0.9%氯化钠注射液100 ml中,ivgtt,qd,连用2周。结果:治疗组的止疱、结痂、疼痛减轻时间均短于对照组(P<0.05);治疗组与对照组的总有效率分别为85.11%、67.44%(P<0.05)。治疗结束1个月后随访,治疗组与对照组后遗神经痛的发生率分别为6.38%、20.93%(P<0.05)。治疗期间两组患者均未发生严重不良反应。结论:单唾液酸四己糖神经节苷脂联合伐昔洛韦治疗老年带状疱疹疗效确切,能显著减少带状疱疹后遗神经痛的发生。

OBJECTIVE： To observe therapeutic efficacy and safety of ganglioside combined with valaciclovir in the treatment of elderly herpes zoster. METHODS： 90 patients with elderly herpes zoster were randomly divided into treatment group （47 patients） and control group （43 patients）. Control group was given Valaciclovir tablet 1 g, bid, for a week; Vitamin B, tablet 10 mg, rid, and Mecobalamin capsules 0.5 mg, tid, for consecutive 2 weeks. Treatment group was additionally given Ganglioside injection 20 mg added into 0.9% Sodium chloride injection 100 ml, ivgtt, qd, for 2 weeks. RESULTS： Cessation time, lesion crusting time and pain relieving time of treatment group were significantly shorter than in control group, there was statistical significance （P〈 0.05）. The effective rate was 85.11% in treatment group and 67.44% in control group （P〈0.05）. In the follow-up investigation one month after treatment, the incidence of post-herpetic neuralgia was 6.38% in treatment group and 20.93% in control group （P〈0.05）. There was no serious ADR in 2 groups during treatment. CONCLUSIONS： Valaciclovir combined with ganglioside is effective for elderly herpes zoster, and also can significantly reduce the incidence of post-herpetic neuralgia.