西妥昔单抗疗效与皮疹相关性的系统评价

Relationship between Efficacy of Cetuximab and Skin Rashes:A Systematic Review

目的系统评价西妥昔单抗疗效与皮疹的相关性。方法计算机检索Pub Med、EMbase、The Cochrane Library(2013年第1期)、CBM、VIP、CNKI等数据库,查找关于西妥昔单抗的皮疹严重程度与疗效相关性的文献,检索时限截至2013年8月。由2位评价员按纳入与排除标准独立筛选文献、提取资料并评价纳入研究的方法学质量后,采用Rev Man 5.2软件进行Meta分析。结果共纳入32个研究,1 543例患者。Meta分析结果显示:发生皮疹患者的治疗有效率明显高于未发生皮疹的患者[RR=1.53,95%CI(1.23,1.91),P=0.000 2],发生重度皮疹患者的治疗有效率明显高于轻度皮疹患者[RR=2.42,95%CI(1.89,3.11),P<0.000 01]。结论西妥昔单抗的疗效与皮疹存在相关性。

Objective To systematically review the relationship between skin rashes and efficacy of cetuximab. Methods Such databases as PubMed, EMbase, The Cochrane Library （Issue 1, 2013）, CBM, CNKI and VIP were systemically searched to collect literature on relationship between the severity of skin rashes and efficacy of cetuximab published up to Aug. 2013. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and evaluated methodological quality of included studies. Then meta-analysis was performed using RevMan 5.2 software. Results A total of 32 studies involving 1 543 patients were included. The results of metaanalysis showed that： the efficacy of cetuximab in patients with skin rashes was significantly superior to patients without skin rashes （RR=1.53, 95%CI 1.23 to 1.91, P=0.000 2）; in addition, the efficacy of cetuximab in patients with severe skin rashes was significantly superior to patients with mild skin rashes （RR=2.42, 95%CI 1.89 to 3.11, P〈0.000 01）. Conclusion Skin rashes are significantly associated with better efficacy of cetuximab.