小陷胸汤化裁治疗糖尿病周围神经病变临床研究

The Clinical Research on Peripheral Neuropathy in Diabetes Mellitus Treated with Xiao Xianxiong Decoction

目的:观察小陷胸汤化裁治疗糖尿病周围神经病变的临床疗效。方法:将36例糖尿病周围神经病变患者随机分为对照组和治疗组各18例。两组均给予科学合理的饮食指导及以胰岛素为主的降糖治疗,对照组在此基础上给予甲钴胺片每次0.5 mg,日3次口服治疗;治疗组则在此基础上给予小陷胸汤化裁治疗,日1剂,两组均以15 d为1个疗程,共治疗2个疗程。治疗前后检测两组患者的血糖、血脂水平,并用肌电图检查两组患者正中神经和腓总神经的感觉传导速度及运动传导速度。结果:两组患者治疗后血糖、血脂水平较治疗前有所降低,以治疗组的降低幅度更为明显,差异有统计学意义(P<0.05);治疗后两组患者的神经传导速度与治疗前相比均有所提高,但是治疗组的升高幅度尤为明显,差异有统计学意义(P<0.05)。结论:小陷胸汤化裁能降低糖尿病周围神经病变患者的血糖、血脂水平,修复神经损伤,提高神经传导速度,疗效显著。

Objective： To observe the clinical effect of Xiao Xianxiong Decoction on peripheral neuropathy in diabetes mellitus.Methods： 36 patients with peripheral neuropathy in diabetes mellitus were randomly divided into the control group and the treatment group,with 18 cases in each group. The patients in both groups were given scientific and reasonable dietary guidance,and insulin-centered glucose-lowering therapy. The patients in the control group were also given mecobalamin tablets for oral administration,0. 5 mg one time,three times a day; while the ones in the treatment group were added Xiao Xianxiong Decoction on the basic treatment of the control group,one dose a day. Both regarded 15 days as a course and were treated for 2 courses continuously. Blood sugar and lipid level of patients in both groups before and after the treatment were tested,and their sensory conduction speed and movement conduction speed of median nerve and peroneal nerve were also tested with EMG. Results： Before the treatment,blood sugar and lipid level between the two groups had no statistical meaning（ P〈0. 05）; After the treatment,blood sugar and lipid level decreased than before the treatment,and the induced degree of the treatment group was more obvious,and their difference had statistical meaning（ P〈0. 05）; Before the treatment,the differences in nerve conduction speed between two groups had no statistical meaning（ P〈0. 05）; After the treatment,nerve conduction speed of both groups increased compared before the treatment,and the increased degree of the treatment group was more obvious,and their difference had statistical meaning（ P〈0. 05）. Conclusion： Xiao Xianxiong Decoction can reduce blood sugar and lipid level of patients with peripheral neuropathy in diabetes mellitus,repair and regenerate nerve injury,improve nerve conduction speed,and has very good curative effect.