李士懋治疗冠心病用药规律分析

Li Shimao's Analysis of the Law of Drug Use for Coronary Heart Disease

目的:分析李士懋教授治疗冠心病的用药规律。方法:收集李士懋教授治疗冠心病的病案,录入中医传承辅助系统,采用该软件集成的规则分析、改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法。结果:李士懋教授治疗冠心病常用药以频次大小前15味药依次为桂枝、制附子、半夏、茯苓、干姜、炙甘草、蒲黄、细辛、黄连、枳实、石菖蒲、白术、丹参、白芍、瓜蒌;使用最多为活血药,其次为温里药,再次为化痰、补气、解表、清热、平肝药;常用药物组合有:桂枝、制附子,炙甘草、桂枝,茯苓、桂枝,干姜、制附子,干姜、桂枝、制附子,细辛、桂枝,干姜、细辛,白术、茯苓,茯苓、制附子,白术、桂枝,干姜、细辛、桂枝,白术、茯苓、桂枝,半夏、茯苓,茯苓、桂枝、制附子等。结论:李士懋教授临床重解表和温里,喜用附子、桂枝、半夏、茯苓、干姜等药。

Objective： To analyze the law of drug use by Professor Li Shimao for treating coronary heart disease. Methods： The cases with coronary heart disease treated by Li Shimao were collected and included in the auxiliary system of TCM inheritance. The methods applied consisted of rule analysis of this software integration,improved mutual information,and data mining of complex system entropy clustering and unsupervised entropy clustering hierarchy. Results： The 15 herbs used by Li Shimao for treating coronary heart disease and listed in order from most to least frequent were Guizhi（ Ramulus Cinnamomi）,Zhifuzi（ Radix Aconiti Lateralis Praeparata）,Banxia（ Rhizoma Pinelliae）,Fuling（ Poria）,Ganjiang（ Rhizoma Zingiberis）,Zhigancao（ Radix et Rhizoma Glycyrrhizae Praeparata cum Melle）,Puhuang（ Pollen Typhae）,Xixin（ Radix et Rhizoma Asari）,Huanglian（ Rhizoma Coptidis）,Zhishi（ Fructus Aurantii Immaturus）,Shichangpu（ Rhizoma Acori Tatarinowii）,Baizhu（ Rhizoma Atractylodis Macrocephalae）,Danshen（ Radix et Rhizoma Salviae Miltiorrhizae）,Baishao（ Radix Paeoniae Alba）,Gualou（ Fructus Trichosanthis）. The most commonly used herbs are the ones for activating blood flow,then for resolving phlegm,tonifying qi,eliminating the external factor,clearing heat and soothing liver. The commonly-used drugs combinations included： Guizhi（ Ramulus Cinnamomi）,Zhifuzi（ Radix Aconiti Lateralis Praeparata）; Zhigancao（ Radix et Rhizoma Glycyrrhizae Praeparata cum Melle）,Guizhi（ Ramulus Cinnamomi）; Fuling（ Poria）,Guizhi（ Ramulus Cinnamomi）; Ganjiang（ Rhizoma Zingiberis）,Zhifuzi（ Radix Aconiti Lateralis Praeparata）; Ganjiang（ Rhizoma Zingiberis）,Guizhi（ Ramulus Cinnamomi）,Zhifuzi（ Radix Aconiti Lateralis Praeparata）; Xixin（ Radix et Rhizoma Asari）,Guizhi（ Ramulus Cinnamomi）; Ganjiang（ Rhizoma Zingiberis）,Xixin（ Radix et Rhizoma Asari）; Baizhu（ Rhizoma Atractylodis Macrocephalae）,Fuling（ Poria）; Fuling（ Poria）,Zhifuzi（ Radix Aconiti Lateralis Praeparata）; Baizhu（ Rhizoma Atractylodis Macrocephalae）,Guizhi（ Ramulus Cinnamomi）; Ganjiang（ Rhizoma Zingiberis）,Xixin（ Radix et Rhizoma Asari）,Guizhi（ Ramulus Cinnamomi）; Baizhu（ Rhizoma Atractylodis Macrocephalae）,Fuling（ Poria）,Guizhi（ Ramulus Cinnamomi）; Banxia（ Rhizoma Pinelliae）,Fuling（ Poria）; Fuling（ Poria）,Guizhi（ Ramulus Cinnamomi）,Zhifuzi（ Radix Aconiti Lateralis Praeparata） etc. Conclusion： Professor Li Shimao puts much emphasis on eliminating the external pathogen and warming the interior. The herbs he commonly used are Fuzi（ Radix Aconiti Lateralis Praeparata）,Guizhi（ Ramulus Cinnamomi）,Banxia（ Rhizoma Pinelliae）,Fuling（ Poria）,Ganjiang（ Rhizoma Zingiberis）,etc.