六味地黄丸及其类方治疗原发性干燥综合征62例

62 Cases with Six Ingredients Rehmannia Pill and Its Analogous Prescriptions for Treating Primary Sjogren Syndrome

目的:观察六味地黄丸及其类方治疗原发性干燥症的临床疗效。方法:将186例原发性干燥症患者按照随机数字法分为3组,对照组患者进行常规治疗,六味地黄丸组患者在常规治疗的基础上口服六味地黄丸,知柏地黄丸组患者在常规治疗的基础山口服知柏地黄丸,3组均持续治疗8周,比较3组患者治疗前后主要实验室检查指标和临床疗效。结果:治疗后,3组患者指标较治疗前明显好转(P<0.05),六味地黄丸组和知柏地黄丸组患者相关指标明显优于对照组(P<0.05),治疗后六味地黄丸组有效率为83.87%,知柏地黄丸组有效率为87.10%,对照组有效率为72.58%,与对照组比较,差异具有统计学差异(P<0.05)。结论:六味地黄丸及其类方治疗原发性干燥症疗效显著。

Objective： To study the clinical effect of Six Ingredients Rehmannia Pill and its analogous prescriptions for treating primary sjogren syndrome. Conclusion： Six Ingredients Rehmannia Pill and its analogous prescriptions have good clinical effects on primary sjogren syndrome. Methods： 186 cases with primary sjogren syndrome were randomly divided into 3 groups. The control group were given routine treatment; the Six Ingredients Rehmannia Pill group were given conventional treatment plus oral administration of Six Ingredients Rehmannia Pill; the Anemarrhena,Phellodendron and Rehmannia Pill group were given routine treatment plus oral administration of Anemarrhena,Phellodendron and Rehmannia Pill. The treatment lasted for 8 weeks. The main laboratory indexes and the efficacy of these three treatment methods before and after the experiment were compared. Results： After the treatment,the patients in each group significantly improved compared with the situation before the treatment（ P〈0. 05）,and indexes of the groups given Six Ingredients Rehmannia Pill and Zhibai Dihuang Pill improved more significantly than the control group did（ P〈0. 05）. The effective rate of Six Ingredients Rehmannia Pill group was 83. 87%; the effective rate of Anemarrhena,Phellodendron and Rehmannia Pill group was 87. 10%,and that of the control group was 72. 58%. The difference between the three groups had with statistical significance（ P〈0. 05）. Conclusion： Six Ingredients Rehmannia Pill and its analogous prescriptions have remarkable effects on primary sjogren syndrome.