摘要
重度主动脉瓣狭窄是老年人中发病率及病死率较高的疾病,经导管主动脉瓣置入术(TAVI)已经成为具有手术禁忌及高风险患者的替代治疗。然而相比于外科瓣膜置换术,TAVI术后更容易发生瓣周漏。研究显示,超过70%的TAVI术后患者会出现不同程度的瓣周漏,与此同时,术后瓣周漏被认为是近、远期死亡的独立危险因素,即使轻度瓣周主动脉反流也会严重影响患者生存率。现通过综合分析文献,对TAVI术后瓣周漏的评估方式、发病机理、处理方法及相关进展做一综述。
Severe aortic stenosis is the main cause of morbidity and mortality in older people. Transcatheter aortic valve implantation（ TAVI） has became an alternative treatment for patients with either a high risk,or a contraindication for surgical operation. However,several studies have demonstrated that up to 70% of all TAVI patients suffer from paravalvular leakage after the procedure,which is higher than with surgical aortic valve replacement. Paravalvular leakage is also an independent predictor of mortality after TAVI,and has a negative effect on prognosis. This review will discuss the current literature with respect to mechanisms,assessment and treatment strategies of paravalvular leakage following TAVI.
出处
《心血管病学进展》
CAS
2015年第1期18-22,共5页
Advances in Cardiovascular Diseases
关键词
主动脉狭窄
经导管主动脉瓣膜置入术
瓣周漏
aortic stenosis
transcatheter aortic valve implantation
paravalvular leakage
