康艾注射液对胃癌细胞SGC-7901的抑制作用

Inhibition Effect of Kangai Injection on Gastric Cancer Cell SGC-7901

目的探讨康艾注射液对胃癌细胞SGC-7901的抑制作用。方法胃癌细胞SGC-7901接受不同浓度康艾注射液,然后采用MTT法测定各组胃癌细胞SGC-7901的增殖情况,Boyden chamber侵袭小室测定各组胃癌细胞SGC-7901侵袭能力,划痕实验测定各组胃癌细胞SGC-7901迁移能力。结果康艾注射液对胃癌细胞SGC-7901增殖的抑制与药物浓度有关(P<0.05),浓度越大,抑制能力越强;康艾注射液对胃癌细胞SGC-7901侵袭、迁移的抑制与药物浓度有关(P<0.05),浓度越大,抑制能力越强。结论康艾注射液对胃癌细胞SGC-7901的增殖、侵袭、迁移均有抑制作用,且具有剂量依赖性。

Objective To investigate the inhibition effect of kangai injection on gastric cancer cell SGC-7901. Methods SGC-7901 cells were treated with different concentration of kangai injection, MTr method was used to detect the cell proliferation of all the groups, boyden chamber was used to detect the invasion ability of all the groups, and wound healing assay was used to detect the migration ability of all the groups. Results The inhibition effect on cell proliferation of SGC-7901 cells was related with the concentration of kangai injection （P 〈 0.05）, the higher the concentration, the stronger the inhibition ability. The inhibition effect on cell invasion and migration of SGC-7901 cells was related with the concentration of kangai injection （P 〈 0.05） ,the higher the concentration,the stronger the inhibition ability. Conclusion Kangai injection can inhibit the cell proliferation,invasion and migration of SGC7901 ceils, and the inhibition effect is dose-dependent.