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血清胸苷激酶1对Ⅳ期结肠癌化疗疗效评估的价值 被引量：6

Value of Serum Thymidine Kinase 1 in the Chemotherapy Efficacy Evaluation for Patients with Stage Ⅳ Colon Cancer
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摘要 目的分析血清胸苷激酶1(S-TK1)对Ⅳ期结肠癌患者化疗疗效评估的价值。方法采用免疫印迹增强化学发光法检测61例Ⅳ期结肠癌患者和41例健康体检者的S-TK1水平。结果Ⅳ期结肠癌患者的S-TK1水平[(3.47±2.33)pmol·L-1]高于健康体检者[(1.07±0.87)pmol·L-1](P<0.05);S-TK1水平与Ⅳ期结肠癌患者的ECOG评分有关(P<0.05);与化疗前比较,化疗后获得疾病控制的Ⅳ期结肠癌患者S-TK1水平呈下降趋势(P<0.05),PD患者S-TK1水平明显上升(P<0.05)。结论监测S-TK1水平对预测Ⅳ期结肠癌的化疗疗效具有一定的价值。 Objective To investigate the clinical value of serum thymidine kinase 1 （S-TK1） in the chemotherapy efficacy evaluation for patients with stage IV colon cancer. Methods Enhanced chemiluminescence assay was used to detect the S-TK1 levels in the 61 patients with stage Ⅳ colon cancer and 41 normal controls. Results The S-TK1 level in the patients stage Ⅳ colon cancer [ （3.47 ± 2.33 ） pmol · L - 1 ] was significantly higher than that in the normal controls [ （ 1,07 ±0.87） pmol · L-1 ] （P 〈0.05） ; the S-TK1 level was statistically related with ECOG scores of the colon cancer （P 〈 0.05 ） ; compared with those before chemotherapy, the S-TK1 levels were significantly decreased in the colon cancer with disease under control after chemotherapy （ P 〈 0.05 ） , the S-TK1 levels were significantly increased in the colon cancer with PD after chemotherapy （P 〈 0.05 ）. Conclusion The detection of S-TK1 may have significance in the chemotherapy efficacy evaluation for colon cancer.
作者 夏莹子 刘永萍 齐秋锋 朱明 张亚平 凌扬
机构地区 苏州大学附属常州肿瘤医院肿瘤实验室及肿瘤内科
出处 《肿瘤基础与临床》 2015年第1期6-8,共3页 journal of basic and clinical oncology
关键词 血清胸苷激酶1 结肠癌 临床疗效 colon cancer serum thymidine kinase 1 clinical efficacy
分类号 R735.35 [医药卫生—肿瘤] R730.43 [医药卫生—肿瘤]
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参考文献10

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同被引文献43

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肿瘤基础与临床
2015年 第1期

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