热疗联合放化疗治疗晚期胰腺癌临床观察

Hyperthermia Combined with Chemoradiotherapy in the Treatment of Patients with Advanced Pancreatic Carcinoma

目的评价聚焦热疗联合调强放疗(IMRT)和经导管肝动脉化疗栓塞(TACE)治疗晚期胰腺癌的临床效果。方法 52例患者按信封法随机分为2组,观察组27例患者采用BSD2000相控阵聚焦热疗联合IMRT和TACE,对照组25例患者采用IMRT和TACE。结果观察组总有效率66.7%、临床受益率92.6%,高于对照组的32.0%和68.0%(P<0.05)。观察组生存状况优于对照组,但差异无统计学意义(P>0.05)。2组毒副反应发生情况比较差异无统计学意义(P>0.05)。结论聚焦热疗联合IMRT和TACE治疗晚期胰腺癌安全有效,能够改善患者生存情况。

l Objective To study the clinical efficacy of BSD2000 deep regional hyperthermia combined with intensity-modulated radiation therapy （IMRT） and transcatheter arterial chemoembolization （TACE） in the treatment of patients with advanced pancreatic carcinoma. Methods Fifty-two patients with advanced pancreatic carcinoma were divided into two groups randomly. Twenty-seven patients of the observation group were treated with BSD2000 deep regional hyperthermia combined with TACE and IMRT,25 patients of the control group were treated with TACE and IMRT. Results The total effective rate and the clinical benefit rate of the observation group （66.7% and 92.6% ） were higher than those of the control group （32.0% and 68.0% ） （ P 〈 0.05 ）. The survival of the observation group was better than that of the control group, but there was no significant difference （ P 〉 0.5 ）. There was no significant difference in the toxicities between the two groups （P 〉 0.5）. Conclusion BSD2000 deep regional hyperthermia combined with IMRT and TACE is effective and safe in the treatment of patients with advanced pancreatic carcinoma.