86例天疱疮患者临床及血清IL-6检测分析

Analysis of Clinical features of 86 patients with pemphigus and detection of the serum interleukin-6

目的通过对86例天疱疮临床病例系统分析,拟从中找出一些规律,更好的指导临床。同时对部分患者进行血清IL-6水平检测,探讨IL-6在天疱疮发病中的作用。方法回顾性分析临床病例;ELISA方法对天疱疮患者血清中IL-6进行检测,并与正常对照进行比较。结果 86例天疱疮患者中33例伴发感染(33/86),感染部位以皮肤最常见(81.8%),病原菌以金黄色葡萄球菌居首位(82.8%),其中MRSA所占比例为37.5%。天疱疮活动组血清IL-6水平高于天疱疮缓解组和正常对照组(P<0.05),天疱疮缓解组与正常对照组差异无统计学意义(P>0.05),合并感染组与未合并感染组血清IL-6水平差异没有统计学意义(P>0.05)。结论天疱疮患者皮肤感染率较高,病原菌以金黄色葡萄球菌为主,经验用药应考虑覆盖这一病原菌;IL-6与天疱疮发病机制有着密切的联系。

Objective To analyze the clinical features of 86 cases with pemphigus for the guidance of clinical treatment, and to investigate the role of ser- um IL-6 in the pathogenesis of pemphigus. Methods The clinical features of 86 patients with pemphigus was retrospectively analyzed, and The level of ser- um IL-6 were detected and compared with normal controls. Results Of 86 cases, there have 33 cases complicated with infection （33/86）, and the common affected area was skin （81.8%）. The most common pathogen was staphylococcus aureus （ 82.8% ）, and the proportion of MRSA was 37.5%. The serum level of IL-6 in patients with disease activity was higher than that of the patients of relieving stage and normal control （ P〈0.05 ）. there was no statistically signifi- cant difference between the patients at relieving stage and normal control （P〉0.05）, also between the patients complicated with infection and without infection （P〉0.05）. Conclusion The probability is higher in the patients with pemphigus complicated with cutaneous infection. The most common pathogen is staphylococcus aureus. IL-6 maybe play an important role in the pathogenesis of pemphigus..