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Th_(17)/Treg细胞在寻常型天疱疮发病机制的研究进展 被引量：1

Progress on Th_(17)/Treg cells in the pathogenesis of pemphigus vulgaris
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摘要 寻常型天疱疮(PV)是一类严重的慢性黏膜-皮肤自身免疫性大疱性皮肤病。Th17细胞和Treg细胞是初始CD4+T细胞在不同的细胞因子诱导下分化出的新亚群,二者的平衡对于维持机体内环境稳定等有重要的意义,近来发现Th17/Treg细胞失衡在PV的发病中发挥重要作用,本文就Th17/Treg细胞在PV发病机制中的作用作一综述。 Pemphigus vulgaris （PV） is a kind of serious, chronic skin mucous membrane-autoimmune bullous dermatosis.Thl7 cells and Treg cells is the differentiated new subsets of initial CD4＋T cells induced by different cyto- kines, which play different biological effects. The balance of both has an important significance for maintaining the body＇s internal environmental stability and it can cause a range of autoimmune diseases after both imbalances. The eti- ology of PV is uncertain, but a number of studies have found that it is closely related to T cell-mediated cellular im- munity, and the imbalance of Th17/Treg cells play an important role in the pathogenesis of PV. The role of Thl7/Treg cells in the pathogenesis of PV has been reviewed in this article.
作者 杨晋 付萍
机构地区 昆明医科大学第二附属医院皮肤性病科
出处 《皮肤病与性病》 2015年第1期25-27,共3页 Dermatology and Venereology
关键词 寻常型天疱疮 TH17细胞 TREG细胞 细胞因子 Pemphigus vulgaris Thl7 cells Treg cells Cytokines
分类号 R751.02 [医药卫生—皮肤病学与性病学] R758.60 [医药卫生—皮肤病学与性病学]
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参考文献29

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二级参考文献89

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皮肤病与性病
2015年 第1期

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