摘要
寻常型天疱疮(PV)是一类严重的慢性黏膜-皮肤自身免疫性大疱性皮肤病。Th17细胞和Treg细胞是初始CD4+T细胞在不同的细胞因子诱导下分化出的新亚群,二者的平衡对于维持机体内环境稳定等有重要的意义,近来发现Th17/Treg细胞失衡在PV的发病中发挥重要作用,本文就Th17/Treg细胞在PV发病机制中的作用作一综述。
Pemphigus vulgaris (PV) is a kind of serious, chronic skin mucous membrane-autoimmune bullous dermatosis.Thl7 cells and Treg cells is the differentiated new subsets of initial CD4+T cells induced by different cyto- kines, which play different biological effects. The balance of both has an important significance for maintaining the body's internal environmental stability and it can cause a range of autoimmune diseases after both imbalances. The eti- ology of PV is uncertain, but a number of studies have found that it is closely related to T cell-mediated cellular im- munity, and the imbalance of Th17/Treg cells play an important role in the pathogenesis of PV. The role of Thl7/Treg cells in the pathogenesis of PV has been reviewed in this article.
出处
《皮肤病与性病》
2015年第1期25-27,共3页
Dermatology and Venereology