中药穴位贴敷治疗原发性肾病综合征水肿临床观察

Clinical Observation on Applying Traditional Chinese Drugs at Acupoints for Edema due to Idiopathic Nephrotic Syndrome

目的：观察中药穴位贴敷治疗肾病综合征水肿的临床疗效。方法：将100例肾病综合征水肿的住院患者按随机方法分为两组各50例。治疗组在西医基础治疗的基础上加用中药穴位贴敷治疗，对照组采用单纯西医基础治疗。7天为1疗程，共2疗程。结果：治疗组总有效率为96．00％（95％CI=82．18％～99．80％），对照组为90．00％（95％CI=73．63％～97．70％），两组综合疗效比较（u=2．7228，P=0．0081），差异有显著性意义；与对照组比较，治疗组可增加尿量（P〈0．05）、减轻水肿（P〈0．01）、减少尿蛋白（P〈0．01）。结论：应用中药穴位贴敷配合西药治疗肾病综合征水肿的临床疗效优于单纯应用西医基础治疗证据尚不够充分，其收益为OR=0．38（95％CI=0．07～2．03，其概率分布跨过1），NNT=17（95％CI=6．25～41．67）。

Objective ： To observe the clinical effect of applying traditional Chinese drugs at acupoints on edema due to nephrotic syndrome. Methods ：100 cases of inpatients with edema due to nephrotic syndrome were randomly divided into two groups of each 50 cases. The treatment group was treated on the basis of western medicine basic treatment plus applying traditional Chinese drugs at acupoints,while the control group was treated alone with west- ern medicine basic treatment. 7 days as a course of treatment, a total of two courses. Results ： The total effective rate of treatment group was 96.00% （95% CI = 82. 18% - 99. 80% ）, the control group was 90. 00% （95% CI = 73.63% -97.70% ）. Compared the comprehensive effects of two groups （ u =2. 722 8 ,P =0. 008 1 ） ,the differ- ence had notable significance;compared with the control group, the treatment group could increase urine volume （P 〈0.05） ,reduced edema （P 〈0. 01 ） and urinary protein （P 〈0. 01 ）. Conclusion：The clinical effect of apply- ing traditional Chinese drugs at acupoints combined with western medicine on edema due to nephrotic syndrome is better than alone with western medicine basic treatment, which has yet not sufficient evidences,its benefits is OR = 0. 38 （95% CI =0. 07 -2.03） ,its probability distribution crosses over 1 ） ,NNT = 17 （95% CI =6.25 -41.67）