摘要
以去甲氨噻肟酸乙酯为起始原料,在相转移催化剂聚乙烯醇400存在下"一锅法"完成水解、醚化反应,精制后得到目标化合物,确定了较优的反应条件,总收率72.8%,纯度98.7%。目标产物的结构均经1HNMR表征。该合成路线原料易得,成本低,操作简单。
Tert-butyl cefixime side chain acid was prepared from ethyl（ Z）-2-hydroxyl- imino-2-（ 2-aminothiazol-4-y1） acetate,in the presence of a phase transfer catalyst polyvinylalcohol 400 via hydrolysis,etherification and purification. The optimum conditions were obtained. The yield was 72. 8% and purity was 98. 7%. The structure of the compound was confirmed by1 HNMR. The synthetic method has advantages on readily available materials,low cost,simple operation.
出处
《化学试剂》
CAS
北大核心
2015年第2期179-180,共2页
Chemical Reagents
关键词
抗生素
头孢克肟
水解
合成
antibiotics
cefixime
hydrolysis
synthesis
