经皮肝穿刺胆道内射频消融内支架置入术与单纯内支架置入术治疗恶性胆道梗阻的临床疗效比较

目的比较胆道内射频消融内支架置入术与单纯支架内置入术治疗胆道恶性肿瘤的临床疗效。方法调查25例实施经皮肝穿刺胆道治疗恶性胆道梗阻患者,其中12例行经皮肝穿刺胆道内射频消融内支架置入术(射频组),13例行单纯内支架置入术(支架组)。所有患者均随访至死亡或术后1年。采用Kaplan-Meier方法比较2组患者的支架开通率及患者的生存期。结果射频组的30 d再阻塞率显著低于支架组(P<0.05)。射频组中位生存期显著长于支架组(P<0.05)。结论胆道内射频消融内支架置入术治疗恶性胆道梗阻临床疗效优于单纯内支架置入术。

Objective To compare the clinical effect of percutaneous biliary radiofrequerncy and endoprothesis with conventional biliary stents in treating malignant biliary obstruction. Methods Twenty ifve patients with malignant biliary obstruction were recruited and divided into two groups, radiofrequerncy and conventional group. Percutaneous biliary radiofrequerncy and endoprothes were performed in twelve patients in radiofrequerncy group while another thirteen patients received conventional biliary stents. All patients were well followed-up until death or at least one year after the procedures. Kaplan Meier analysis was used to compare the patients` survival rate and stent patency rates. Results Both mortality rate and reobstruction rate were lower in radiofrequerncy group than these in conventional group (all P<0.05). Conclusion Compared with the conventional interventional therapy, radiofrequency can reduce the re-obstruction rate as well as the postoperative survival rate of the patients with malignant biliary obstruction. Radiofreuerncy and endoprothesis is superior to simple biliary stents in treating malignant biliary obstruction.