胃癌术后患者202例预后因素分析

Prognosis factors analysis of 202 patients with gastric cancer after resection

目的分析胃癌术后影响患者预后的因素,为优化胃癌的治疗、改善胃癌患者的预后提供线索。方法选取2005年1月至2008年1月在重庆市九龙坡区属各综合二级甲等医院行胃癌切除术患者202例,对其临床病理特征和术后辅助化疗等进行统计分析。结果 202例患者总体术后1、3、5年累积生存率分别为93.56%(189/202)、77.72%(157/202)、34.16%(69/202)。肿瘤直径大小、肿瘤的浸润深度、肿瘤分化程度、肿瘤的淋巴结转移数目及肿瘤TNM分期是胃癌根治术患者的独立预后因素(P<0.05)。结论肿瘤的区域淋巴结转移数目、肿瘤分化程度、肿瘤的直径、肿瘤的浸润深度以及肿瘤的TNM分期可以作为临床判断胃癌预后及优化治疗方案的依据。

Objective To explore the prognosis factors of the patients with gastric cancer after the surgery to offer the ref-erences to optimize the treatment of gastric cancer and improve their prognosis. Methods A total of 202 patients with gastric cancer after resection in the grade-A class-two comphrehensive hospitals in Jiulongpo District of Chongqing City from January 2005 to January 2008 were selected,and conducted analysis of their pathological features and postoperative chemotherapy. Results A mong 202 patients,the overall survival rates of 1,3,5 years after the surgery were 93.56%（189/202）,77.72%（157/202） and34.16%（69/202） in succession. The study instructed that the tumor size,depth of invasion,differentiated degree,lymphatic metastasis quantity and TNM staging were independent prognosis factors of gastric cancer after resection（P〈0.05）. Conclusion Tumor size,lymphatic metastasis,depth of invasion,number of metastatic nodes,TNM stages can be used to prognosis and treatment regimen of gastric cancer patients who received radical resection. The lymphatic metastasis quantity,differentiated degree,tumor size,depth of invasion and TNM staging were deemed as the reference of judgement of gastric cancer prognosis and treatment optimization.