超敏C反应蛋白和白细胞计数联合检测在儿童细菌性感染诊断中的意义

Clinical significance of testing of high sensitivity C-reactive protein combined with white blood cell count for the children bacterial infection diseases diagnosis

目的探讨对儿童细菌性感染实施超敏C反应蛋白和白细胞计数联合检测的临床意义。方法选择2013年1月至2014年3月被确诊为细菌性感染的患儿94例设为观察组,选择同期体检并健康的儿童95例设为对照组,所有纳入儿童都进行超敏C反应蛋白水平的检测,同时计数全血样本中白细胞数量,统计分析结果。结果与对照组比较,观察组患儿血清中超敏C反应蛋白水平和白细胞数量均明显升高,差异均有统计学意义(P<0.05);观察组患儿在经过1个疗程的治疗后发现其血清中超敏C反应蛋白和白细胞数量较治疗前出现明显下降,差异有统计学意义(P<0.05)。观察组患儿单独检测超敏C反应蛋白和白细胞计数阳性率分别为76.60%(72/94)和78.72%(74/94),均低于两指标联合检测阳性率[95.75%(90/94)],差异均有统计学意义(P<0.05)。结论超敏C反应蛋白和白细胞计数都是辅助诊断儿童细菌性感染的良好指标,二者联合检测可以降低漏诊率。

Objective To explore the clinical significance of testing of high sensitivity C-reactive protein combined with white blood cell count for the children bacterial infection diseases diagnosis. Methods A total of 94 children patients who were diagnosed bacterial infection diseases from January 2013 to March 2014 were deemed as the observation group,while another 95 healthy children through physical examination as the control group. All the children were detected high sensitivity C-reactive protein concentration,counting the white blood cells quantity,analyzing the results comprehensively. Results Compared to the control group,It was significantly higher of the observation group in the high sensitivity C-reactive protein and white blood cell count,which was statistical significant in differences（P〈0.05）. After a course of treatment,the children patients in the observation group was lower than those in the control group in the high sensitivity C-reactive protein and white blood cell count,whose difference had statistical significance（P〈0.05）. The positive rates of high sensitivity C-reactive protein and white blood cell count were76.60%（72/94） and 78.72%（74/94） respectively,and the positive rate of the joint detection was 95.75%（90/94）,which was statistical significant in differences（P〈0.05）. Conclusion Both the high sensitivity C-reactive protein and white blood cell count are good reference to diagnose children bacterial infection diseases,which may reduce the missed diagnosis when they are jointed detected.