期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血清胰岛素样生长因子结合蛋白-2在消化道肿瘤中的研究进展 被引量：2

下载PDF
导出
摘要 我国的消化道肿瘤发病率逐年增高,近年来,国内外对该类疾病的发生机制、发展过程及生物学标记物的研究已进入基因和蛋白组学水平。有研究发现,血清胰岛素样生长因子结合蛋白-2（insulin-like growth factorbinding protein-2,IGFBP-2）在消化道恶性肿瘤,如肝癌、胃癌、结直肠癌、胰腺癌等的癌组织和患者体液中均有表达,表明IGFBP-2可能与消化道肿瘤的发生、发展及其预后有关。
作者 方超 雷正明
机构地区 泸州医学院附属医院肝胆外科
出处 《现代医药卫生》 2015年第4期538-540,共3页 Journal of Modern Medicine & Health
关键词 胰岛素样生长因子结合蛋白质2/血液 载体蛋白质类 消化系统肿瘤/血液 研究进展
分类号 R730.264 [医药卫生—肿瘤]
  • 相关文献

参考文献26

  • 1杨帆.胰岛素样生长因子结合蛋白-2水平与肝癌关系的研究[J].临床外科杂志,2007,15(7):451-453. 被引量：2
  • 2Sunderic M, Dukanovic B, Malenkovic V,et al. Molecular forms of the in- sulin-like growth factor-binding protein-2 in patients with coloreetal can- cer[J]. Exp Mol Pathol, 2014,96 (1) :48-53.
  • 3Ansari D, Aronsson L, Sasor A,et al. The role of quantitative mass spec- trometry in the discovery of pancreatic cancer biomarkers for translational science[J]. J Transl Med,2014,12 : 87.
  • 4Carrick FE, Forbes BE, Wallace JC. BIA core analysis of bovin einsu lin- like growth factor (IGF)-binding protein-2 identifies majorIGF binding site determinantsin both amino- andcarboxy-1 terminadomains[J]. J Biol Chem,2001,276(29) :27120-27128.
  • 5Schutt BS,Langkamp M, Rauschnahel U,et al. Integrin-mediatedaetion of insulin-like growth factor binding protein-2 in tumor cells[J]. J Mol En- docrinol, 2004,32 (3) : 859-868.
  • 6Foulstone E J, Zeng L, Perks CM, et al. Insulin-like growth factor binding protein 2 (IGFBP-2) promotes growth and survival of breast epithelial cells: novel regulation of the estrogen receptor[J]. Endocrinology, 2013,154 (5): 1780-1793.
  • 7Hoeflich A, Reisinger R,Vargas GA,et aL Mutation of the RGD sequence does not affectplasm amembrane association and growth inhibitory effects of elevated IGFBP-2 in vivo[J]. FEBS Lett, 2002,523 (1/2/3) : 63-67.
  • 8Conover CA,Clarkson JT, Bale LK. Factors regulating insulin-like growthfactor-binding protein-3 binding,processing, and potentiation of insulin- likegrowth factor action[J]. Endocrinology, 1996,37 (6) : 2256-2292.
  • 9Zhou QI, Mao YQ, Jiang WD, et al. Development of IGF signaling antibody arrays for the identification of hepatocellularcarcinoma biomarkers[J]. PLoS One,2012,7(10) :e46851.
  • 10Zhang Y,Ying X,Han S, et al. Autoantibodies against insulin-like growth factor-binding protein-2 as a serological biomarker in the diagnosis of lung cancer[J]. IntJ Oncol, 2013,42 ( 1 ) : 93-100.

二级参考文献19

  • 1Vrieling A, Rookus MA, Kampman E, et al. Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk. J Nutr,2007,137 (2) :379-383.
  • 2Sabattini E, Bisgaard K, Ascani S, et al. The EnVision + + system: a new immunohlstechemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques. J Clin Pathol,1998, ;51 (7) :506-511.
  • 3Williams RJ. Tfichostatin A. An inhibitor of histone deacetylase , inhibits hypoxiainduced angiogenesis. Expert Opin Investig Drugs, 2001, 10: 1571-1573.23.
  • 4Eiseman JL,Guo J, Ramanathan RK, et al. Evaluation of Plasma Insulin-like Growth Factor Binding Protein 2 and Her-2 Extracellular Domain as Biomarkers for 17-Anylamino-17-Demethoxygeldanamyein Treatment of Adult Patients with Advanced Solid Tumors. Clin Cancer Res,2007,13 (7) :2121-2127.
  • 5Busund LT, Richardsen E, Busund R, et al. Significant expression of IGFBP2 in breast cancer compared with benign lesions. J Clin Pathol, 2005,58(4) :361-366.
  • 6Sato H, Yazawa T, Suzuki T, et al. Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia. Am J Pathol,2006,169(5) :1550-1566.
  • 7Stattin P,Bylund A,Rinaldi S,et al.Plasma insulin like growth factor1、inslunin-like growth factor binding proteins.and prostate cancer risk:a prospective study[J].J Natl Cance lnat,2000,92(7):1910-1917.
  • 8Takeda S,Kondo M,Kumada T.AUelic expression of the insulin-like growthfactor 2 gene in hepatocellular carcinoma and underlying disease[J].Oncogene,1996,12(6):1589-1592.
  • 9Yang EB,Qin LL,Zhao YN,et al.Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor Ⅱ receptor gene in human hepatitis B virus-associated hepatoceUular carcinoma[J].Int J Mol Med,2003,11(6):773-778.
  • 10Collett-Solberg PF,Cohen P.Genetics,chemistry,and function of the IGF/IGFBP system[J].Endocrine,2000,12(2):121-136.

共引文献7

同被引文献15

引证文献2

二级引证文献11

现代医药卫生
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部