同型半胱氨酸与主要慢性病关系研究进展

Advances in researches of homocysteine and major chronic diseases

近年来,高同型半胱氨酸血症(Hhcy)作为多种慢性病的独立危险因素,越来越引起人们的重视;与同型半胱氨酸(Hcy)升高有关的激素、营养、遗传等因素也同样被认为与心血管疾病、脑卒中、高血压、糖尿病、慢性阻塞性肺疾病(COPD)、癌症等慢性病有着密切的关系;大量的动物实验和临床研究显示,Hcy能够刺激血管平滑肌增生以及造成血管内皮损伤等,从而增加多种慢性发病的危险性。

In recent years, hyperhomocysteinemia, as an independent risk factor for many chronic diseases, attracts more and more attentions of research. Numerous nutritional, hormonal, and genetic factors related to the increased homo- cysteine concentration are also associated with specific pathological conditions,including cardiovascular diseases, stroke, hypertension, diabetes mellitus, chronic obstructive lung disease, and cancer. A large number of animal experiments and clinical studies show that homocysteine can stimulate the proliferation of vascular smooth muscle and cause endothelial injury, thus increasing the risk of a variety of chronic disease.