神经生长因子及其在支气管哮喘中的研究进展

Nerve growth factor and its research progress in bronchial asthma

支气管哮喘（简称哮喘）作为呼吸系统中呈逐年上升趋势的一种常见病，给人类社会及家庭均带来了严重的经济负担。尽管激素的使用对哮喘患者的症状有所控制，但激素敏感的出现等，使其发病率和病死率只增不减，追根溯源还是对哮喘的发病机制不完全了解所致，故完善其发病机制的研究，将开拓新的诊疗方向。随着现代分子生物学的发展，目前发现神经生长因子在哮喘的发生发展中起着核心作用，有学者提出了哮喘的“免疫-神经-内分泌网络”的概念，通过多系统的联系，使人们对哮喘的发病机制有了更深的认识，或许将开拓哮喘研究及治疗的新领域。

Bronchial asthma （asthma） is a common disease which is being growth trend in the respiratory system,and brought serious economic burden for human＇ society and families. As the use of hormones, some symptoms of asthma may be controlled. However, its morbidity and mortality is still increasing because of the presence of the hormone sensitive and so on. Tracing the reason is not clearly about the pathogenesis of asthma. So consummating the research of the asthma pathogenesis will develop new therapeutic direction. With the development of modern molecular biology, nerve growth factor was found that it plays a core role in the occurrence and development of asthma. Some scholars proposed the ＂ immune nerve-endocrine network＂ of asthma. Through linking with the multiple system may make people had a deeper understanding of pathogenesis of asthma. Perhaps, it will explore the new areas about the research and treatment of asthma.