脂肪因子与支气管哮喘相关性的研究进展

Research progress of the association of adipokines and bronchial asthma

肥胖和支气管哮喘（简称哮喘）的发病率均逐年增加，已经成为重要的社会经济问题，给社会和家庭带来沉重的负担。近十年来大量研究提示肥胖和哮喘之间存在关联，甚至提出肥胖型哮喘是一种新的疾病。但其发病机制目前尚未明确。脂肪因子是肥胖的特征性物质，已有较多研究发现脂肪因子与哮喘之间存在相关性，本文就3种主要的脂肪因子（瘦素、脂联素和抵抗素）在哮喘中的作用作一综述，探讨哮喘与脂肪因子之间可能的关系。

Epidemiologic data indicate an increasing morbidity of obesity and bronchial asthma （asthma）. Over the past decades, obesity and asthma have become the two major global public health challenges. Many researches show a significant association between obesity and asthma, and define obese asthma as a new disease. But the mechanism does not been clearly understood. Adipokines are characteristic substances of obesity, many studys have found a relationship between adipokines and asthma. This review focused on the effect of three main adipokines （leptin, adiponectin and resistin） in asthma,and explored the potential relationship between adipokines and asthma.