过敏性支气管哮喘免疫发病机制的最新研究进展

Progress of the immunopathogenesis of allergic bronchial asthma

过敏性支气管哮喘（简称哮喘）是一种由不同的辅助性T细胞亚型决定的慢性气道炎症性疾病。既往认为“Th2哮喘假说”是过敏性哮喘的主要发病机制，而越来越多的研究表明，除了Th2之外其他辅助性T细胞也参与了哮喘的发病机制，尤其是Th1和Th17细胞对于气道中性粒细胞型炎症的发展至关重要。抑制这些免疫细胞也许为过敏性哮喘的有效治疗提供了方向。

Allergic bronchial asthma （asthma） is a chronic obstructive airway disease that involves inflammation of the respiratory tract which was largely determined by the involvement of different T helper cell subsets. It is well known that ＂Th2 asthma hypothesis＂ is the main pathogenesis of allergic asthma,however, more and more evidences demonstrate that T helper cells other than Th2 cells are involved in the pathogenesis of allergic asthma, specifically, both Thl and Th17 cells are crucial for the development of neutrophilic inflammation in the airways. Devetopment of therapeutics that suppress these immune and inflammatory cells may provide useful allergic asthma treatments in the future.