Treg/Th17与慢性阻塞性肺疾病的研究进展被引量：6

Research progress of Treg/Th17 and chronic obstructive pulmonary disease

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摘要慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是气道的炎性病症,以慢性进展和不可逆的气流受限为特征。研究表明自身免疫反应参与本病的发病机制。调节性T细胞(regulatory T-cells,Treg)和辅助性T细胞17(T helper 17 cells,Th17)是CD4+T淋巴细胞的两个亚群,是已知的重要的免疫调节细胞,牵涉到多种炎性和自身免疫性疾病的发病机理,并在气道炎症和慢性阻塞性肺病的发病机制中起到重要作用。两者在功能和分化过程中相互拮抗,该平衡关系的维持或破坏对于免疫或炎症性疾病的发病具有重要意义。 Chronic obstructive pulmonary disease （COPD） is a kind of disease about airway inflammation. R is a disease state characterized by airflow limitation that is not fully reversible and is progressive slowly. Recent research indicates that autoimmune reaction involved in the pathogenesis of this disease. CD4＋ T-lymphocytes includes regulatory T-cells （Treg） and T helper 17 cells （Thl7）, which are both important immune regulatory cells and then involved in a series of pathogenesis of inflammatory and autoimmune related disease, furthermore play an important role in the pathogenesis of airway inflammation and chronic obstructive pulmonary disease. ~hey are mutually antagonistic in function and differentiation, once the balance relationship is destroyed, it will have very important significance in immune or inflammatory disease.

作者田静戴爱国蒋永亮

机构地区南华大学附属马王堆医院湖南省老年医院呼吸疾病研究室

出处《临床与病理杂志》 CAS 2015年第1期140-144,共5页 Journal of Clinical and Pathological Research

基金湖南省科技计划项目(2011FJ6048) 湖南省科技计划重点项目(2012SK2006)~~

关键词调节性T细胞辅助性T细胞17 慢性阻塞性肺疾病 regulatory T cells helper T cells 17 chronic obstructive pulmonary disease

分类号 R563.9 [医药卫生—呼吸系统]

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