摘要
目的探讨子痫前期患者血清转化生长因子β(TGF-β)、肿瘤坏死因子α(TNF-α)和干扰素γ(IFN-γ)水平变化及其临床意义。方法选取子痈前期产妇32例(轻度子痫前期组22例、重度子痫前期组10例)、妊娠期高血压疾病30例(妊娠期高血压疾病组)和正常产妇30例(正常产妇组)做为研究对象。检测分娩前血清TGF-β、TNF-α和IFN-γ浓度,分析不良妊娠结局与上述指标的关系。结果重度子痫前期组血清TGF-β[(90.4±23.4)μg/L]、TNF-α[(84.5±13.5)μg/L]和IFN-γ[(145.5±13.4)μg/L]水平显著高于正常产妇组[(11.3±3.7)μg/L、(5.5±1.2)μg/L、(82.5±19.4)μg/L]、妊娠期高血压疾病组[(35.3±8.4)μg/L、(10.4±2.9)μg/L、(96.4±15.8)μg/L]、轻度子痫前期组[(76.5±15.4)μg/L、(26.5±3.2)μg/L、(120.4±20.5)μg/L],差异有统计学意义(F值分别为11.363、15.982、7.431,P均〈0.001);轻度子痫前期组血清TGF—β、TNF-α和IFN-γ水平显著高于正常产妇组、妊娠期高血压疾病组(P均〈0.05)。TGF—β、TNF-α、IFN-γ高表达患者早产的发生率显著高于低表达患者(7例与2例,)(2=4.037,P=0.044)。TGF—β、TNF-α表达患者胎儿生长受限的发生率显著高于低表达患者(6例与1例,x2=4.969,P=0.025)。结论检测妊娠孕妇血清各项细胞因子的变化可在一定程度上评估孕妇子痫前期的严重程度及对不良妊娠结局进行预测。
Objective To investigate the clinical significance of serum transforming growth factor-β(TGF-β), tumonecrosifactor-α(TNF-α ) and interferon γ (IFN-γ) levelin patientwith preeclampsia. MethodThirty-two caseof maternal pre-eclampsia(22 casewere mild pre-eclampsia, 10 casewere severe pre-eclampsia) ,30 caseof gestational hypertension and 30 caseof normal motherwere selected aousubjects. Serum TGF-β、TNF-α、IFN-γ levelwere detected. Adverse pregnancy outcomein patientwere collected and analyzed. ResultSerum IFN-γ levelin patientwith severe pre-eclampsiwere (90. 4 223.4) μg/L, (84, 5 ± 13.6)μg/L and ( 146. 5 ±13.4)μg/L respectively, significantly highethan thain normal mother( ( 11.3 ± 3.7 ) μg/L, ( 5.6± 1.2 ) μg/L and ( 82. 5± 19.4 ) μg/L), the gestational hypertension group ( ( 35. 3 ± 8.4 )μg/L, ( 10. 4 ± 2. 9 ) μg/L and ( 96.4 ± 15. 8 ) μg/L), and mild preeclampsigroup ( ( 76. 5 ± 15.4 ) μg/L, ( 26. 5 ± 3.2 )μg/L and ( 120.4 ± 20. 5 )μg/L), and the difference were significant( F = 11. 363,15. 982,7. 431 ;P 〈0. 001 ). Serum TGF-β、TNF-α and IFN-γ levelin mild preeclampsiwere significantly highethan those in normal motherand gestational hypertension patient(P 〈 0. 05 ). Incidence of preterm delivery in patientwith high TGF-β、TNF-α、IFN-γ expression wasignificantly highethan patientwith low expression ( 7 casevs. 2 case; X2 = 4. 037, P = 0. 044 ). Incidence of in patientwith high FGR,TGF-β、TNF-α expression wasignificantly highethan patientwith low expression (6 casevs. 1 case; X2 = 4. 969, P = 0. 025 ). Conclusion Detection of maternal serum cytokinecan evaluate the severity of pre-eclampsito certain extenand predicted adverse pregnancy outcomes.
出处
《中国综合临床》
2015年第2期177-180,共4页
Clinical Medicine of China