摘要
黄酮醇即3-羟基黄酮,是一类独特的黄酮化合物,广泛存在于植物界中,具有许多重要的生物活性和药理作用,其化学合成研究一直备受关注.综述了黄酮醇骨架的4种主要合成方法:Auwers法,查尔酮氧化关环即Algar-Flynn-Oyamada(AFO)反应,Baker-Venkataraman法,黄酮DMDO(3,3-二甲基双环氧乙烷)氧化法;并对多羟基黄酮醇的区域选择性甲基化、异戊烯基化和糖苷化等衍生化方法进行了概述.
Flavonols, also known as 3-hydroxyflavones, are a kind of unique flavonoids that widely distributed in the plant kingdom, and have been associated with a wide variety of biological activities and pharmaceutical applications. Four principal synthetic approaches to flavonol skeleton including Auwers synthesis, Algar-Flynn-Oyamada reaction (AFO), Baker-Venkataraman synthesis and flavone oxidation by 3,3-dimethyldioxirane (DMDO) are summarized. The regioselective methylation, prenylation and glycosylation ofpolyhydroxyl flavonols are presented as well.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2015年第1期70-84,共15页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21172214)资助项目~~
关键词
黄酮醇
合成
AFO反应
衍生化
区域选择性
flavonol
synthesis
AFO reaction
derivatization
regioselectivity