3-吗啉基氟化硼络合二吡咯甲川类化合物的合成及反应机理研究

Synthesis and Mechanism Study of 3-Morpholin Borondipyrrolemethene Derivatives

以对羟基苯甲醛和吡咯为原料,合成了3-吗啉-8-[4'-(3-吗啉丙氧基)苯基]氟化硼络合二吡咯甲川和3-吗啉-8-(4'-甲氧基苯基)氟化硼络合二吡咯甲川,其结构经过1H NMR和LC-MS分析表征,通过相似性试验和晶体的培养对吗啉直接取代氟化硼络合二吡咯甲川(BODIPY)类化合物3-H的反应机理进行研究.

Two new 3-morpholin boron-dipyrrolemethene （BODIPY） derivatives, 4,4-difluoro-8-[4＇-（3-morpholinopropoxy）- phenyl]-3-morpholin-4-bora-3a,4a-diaza-s-indacene and 4,4-difluoro-8-（4-methoxyphenyl）-3-morpholin-4-bora-3a,4a-diaza- s-indacene, were designed and synthesized from p-hydroxybenzaldehyde and pyrrole. The key intermediates and the target compounds were characterized by 1^H NMR and LC-MS. The mechanism of direct functionalization of BODIPY dyes at the 3-position was investigated with similarity experiments and the crystal structure.