新生儿呼吸道分离凝固酶阴性葡萄球菌耐药性分析

Resistance analysis of coagulase negative staphylococcus in newborn respiratory tract samples

目的探讨新生儿呼吸道感染凝固酶阴性葡萄球菌(CNS)的耐药特点,指导临床合理用药和预防院内感染。方法采用K-B纸片扩散法,测定CNS对l6种抗菌药物的耐药性。结果 1 332例新生儿呼吸道标本中检出CNS 132例,阳性率10.1%,其中耐甲氧西林CNS检出14例,占CNS的10.6%。132例CNS对青霉素类(97.7%)、红霉素(77.3%)、克林霉素(57.6%)耐药率较高,对头孢吡肟(7.2%)和头孢哌酮/舒巴坦(9.7%)耐药率较低,对万古霉素、替考拉宁、利奈唑胺全部敏感。结论 CNS为新生儿呼吸道感染的重要致病菌,临床医生应根据新生儿感染CNS的药物敏感试验结果合理使用抗菌药物。

Objective To explore drug resistance characteristics of neonatal respiratory infections coagulase‐negative staphylococci （CNS）, and to guide clinical rational drug use and to prevent nosocomial infection. Methods K‐B disk diffusion method was used to determinate CNS on l6 antimicrobial drug resistance. Results CNS 132 cases were detected from 1 332 cases of neonatal respiratory specimens, the positive rate was 10. 1%, in which MRCNS de‐tected in 14 cases, accounting for 10. 6% of coagulase‐negative staphylococci. And 132 coagulase‐negative staphylo‐cocci had higher resistance rates to penicillin （97. 7% ）, erythromycin （77. 3% ）, clindamycin （57. 6% ） ;had lower re‐sistance rates to cefepime （7. 2% ） and cefoperazone/sulbactam （9. 7% ）, and with all sensitive to vancomycin, teico‐planin, linezolid. Conclusion CNS might be important pathogenic bacteria for neonatal respiratory tract infection, cli‐nicians should rational use of antimicrobial drugs based on the results of drug susceptibility testing of newborns infec‐ted with CNS.