摘要
目的探讨糖尿病酮症酸中毒(DKA)患者血清硫胺素水平改变及临床意义。方法连续性收录2012年6月至2014年6月太和县人民医院收治的62例DKA患者,根据是否缺乏硫胺素将患者分为硫胺素正常组(对照组)和低硫胺素组。检测患者血糖、血乳酸、肌酐等生化指标。结果低硫胺素组硫胺素水平为(5.6±2.1)nmol/L,明显低于对照组的(15.4±5.1)nmol/L,差异有统计学意义(P<0.05);低硫胺素组患者乳酸水平为(5.5±1.3)mmol/L,明显高于对照组的(1.2±0.3)mmol/L,差异有统计学意义(P<0.05)。相关性分析提示,硫胺素与血乳酸水平、APACHEⅡ积分呈负相关,r分别为-0.44、-0.48,差异有统计学意义(P<0.05)。结论 DKA患者中硫胺素缺乏与高乳酸状态密切相关,是判断DKA病情及预后的重要指标之一。
Objective To evaluate the clinical value of thiamine in diabetic ketoacidosis （DKA） patients. Meth‐ods A total of 62 DKA patients from June 2012 to June 2014 were enrolled in this study and divided into two group based on the levels of thiamine ：thiamine insufficient group and thiamine sufficient group（control group）. Blood glu‐cose, lactate and creatinine were tested. Results The levels of thiamine in thiamine insufficient group （5. 6 ± 2. 1） nmol/L were lower than control group（15. 4 ± 5. 1）nmol/L（P〈0. 05）. The contents of lactate in thiamine insuffi‐cient group（5. 5 ± 1. 3）mmol/L were higher than control group（1. 2 ± 0. 3）mmol/L（P〈 0. 05）. Thiamine showed negative relationship with lactate （r= -0. 44, P〈0. 05） and APACHE Ⅱ scores（r= -0. 48, P〈0. 05）. Conclusion Thiamine is closely related to high state of lactic acid in DKA patients, which may become an important indexes to judge DKA condition and prognosis.
出处
《检验医学与临床》
CAS
2015年第3期358-359,362,共3页
Laboratory Medicine and Clinic
