酚妥拉明 多巴酚丁胺联合血栓通治疗慢性肺心病急性加重期疗效观察

Clinical observation of phentolamine,dobutamine and xueshuantong in the treatment of 60 patients with acute exacerbation of chronic pulmonary heart disease

目的观察酚妥拉明、多巴酚丁胺联合血栓通治疗慢性肺心病急性加重期的疗效。方法将120例肺心病急性加重期患者随机分为观察组和对照组各60例,对照组采用常规基础治疗,观察组在常规基础治疗的基础上给予酚妥拉明、多巴酚丁胺联合血栓通治疗,10 d后观察疗效。结果观察组显效40例,有效16例,无效4例。对照组显效26例,有效15例,无效19例。两组疗效比较差异有统计学意义(P<0.01)。两组治疗后心功能和血流动力学及血气分析各项指标均明显改善(P<0.05),观察组优于对照组,差异有统计学意义(P<0.01)。结论在常规基础治疗的基础上加用酚妥拉明、多巴酚丁胺联合血栓通治疗可明显改善慢性肺心病急性加重期的疗效。

Objective To observe the clinical efficacy of phentolamine, dobutamine, and xueshuantong in the treatment of acute exacerbation of chrohic pulmonary heart disease. Methods One hundred and twenty patients with acute exacerbation of chronic pulmonary heart disease were randomly divided into observation group and control group with 60 patients in each group. The control group was treated with conventional therapy, and the observation group was treated with phentolamine, dobutamine combined with xueshuantong on the basis of conventional therapy. The therapeutic efficacy were observed after 10 days of treatment. Results The curative effect of the observation group showed was excellent in 40 patients, effective in 16 patients, noneffective in 4 patients. The curative effect of the control group showed marked was excellent in 26 patients, effective in 15 patients, no effect in 19 patients, there was a significant difference in the therapeutic efficacy between two groups（P 〈 0. 01 ）. After treatment all indexes of cardiac function and hemodynamics and blood gas analysis were improved significantly in two groups （P 〈 0. 05 ） , but the observation group was better in improving the above indexes compared with in the control group（ P 〈 0.01 ）. Conclusion On the basis of the conventional therapy, the use of phentolamine, dobutamine combined with xueshuantong in the treatment of patients with acute exacerbation of chronic pulmonary heart disease has better curative effects.