间苯三酚在青少年无痛人工流产术中的临床观察

Clinical observation on the effect of phloroglucin in adolescent painless induced abortion

目的探讨应用间苯三酚在青少年无痛人工流产术中的疗效。方法选择2011年1月至2014年5月来涞源县妇幼保健院门诊要求人工流产术的青少年孕妇52例,年龄14-19岁,随机将其分为2组,观察组27人,对照组25人。观察组在术前10 min静脉注射间苯三酚80 mg,然后静脉注射丙泊酚1.50-2.50 mg/kg至患者意识消失,然后行人工流产术。对照组单纯使用丙泊酚行无痛人工流产术。观察宫口松弛程度、手术时间、镇痛效果及并发症发生情况。结果观察组的镇痛有效率是96.29%,对照组的有效率88.00%,2组比较有统计学意义（P〈0.05）。观察组宫口松弛程度、手术时间及并发症的发生和对照组比较,有统计学意义（P〈0.05）。结论无痛人流联合使用丙泊酚,增强了镇痛效果,有效改善宫口松弛程度,缩短手术时间,减少并发症的发生。故值得临床广泛推广。

ObjectiveTo investigate the effect of preoperative application of phloroglucin in adolescent painless induced abortion.Methods Between January, 2011, and May, 2014, 52 adolescent pregnant women requiring induced abortion in our out-patient department, aged 14 to 19 years old, were randomly divided into two groups. 27 patients in observation group and 25 in control group. Before the start of the operation for 10 min, the patients in the observation group were given 80 mg phloroglucin intravenously, then 1.50-2.50 mg/kg propofol intravenuously until the patients lost consciousness, and then received the induced abortion. Patients in control group were only treated with propofol with the same dose for painless induced abortion. Observation index included uterus lfabby degree, operation time, analgesic effect and the occurrence of artiifcial abortion syndrome.Results The effective rate of analgesia was 96.29% in the observation group, and 88.00% in control group. There were signiifcant differences between two groups （P〈0.05）. There was also signiifcant difference between two groups in the uterus flabby degree, operation time and the occurrence of induced abortion syndrome control group （P〈0.05）. Patients in the observation group had no complications, while one patient in the control group appeared complication of uterine perforation because of tight Uterus.Conclusion The application of phloroglucin intravenously in adolescent painless induced abortion, can signiifcantly enhance the analgesic effect, effectively improve the uterus lfabby degree, shorten the operation time, reduce the incidence of induced abortion syndrome. Therefore it can be used to reduce the occurrence of complications, which is worthy to be distributed in clinical practice.