期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

微小RNA在乳腺癌干细胞中的作用

The role of microRNAs in breast cancer stem cells
原文传递
导出
摘要 肿瘤干细胞是一类具有自我更新以及多向分化潜能的特殊肿瘤细胞群,在肿瘤形成、转移、抗癌治疗和癌症复发中发挥着显著作用.大量研究发现,微小RNA参与了调节乳腺癌干细胞的维持、生长以及习性,为乳腺癌的诊断、预后和治疗开辟了新的途径. Cancer stem cells are a kind of cancer cell group with the ability of self-renewal and various diferentiation potentials.Recent studies have implicated that they play a significant role in tumor formation,metastasis,resistance to anticancer therapies and cancer recurrenee.Many studies show that microRNAs are involved in the maintenance,growth and behavior of breast cancer stem cells （BCSCs）,paving a new way for diagnosis,prognosis and therapy of breast cancer.
作者 茅昌飞 吴建中 唐金海
机构地区 南京医科大学附属江苏省肿瘤医院普外科
出处 《国际肿瘤学杂志》 CAS 2014年第12期884-887,共4页 Journal of International Oncology
关键词 微RNAS 肿瘤干细胞 乳腺肿瘤 MicroRNAs Neoplastic stem cells Breast neoplasms
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献18

  • 1Wicha MS,Liu S,Dontu G.Cancer stem cells:an old idea--a paradigm shift[J].Cancer Res,2006,66(4):1883-1890.
  • 2Nana-Sinkam SP,Croce CM.Clinical applications for micrornas in cancer[J].Clin Pharmacol Ther,2013,93(1):98-104.
  • 3Sempere LF,Christensen M,Silahtaroglu A,et al.Altered microrna expression confined to specific epithelial cell subpopulations in breast cancer[J].Cancer Res,2007,67(24):11612-11620.
  • 4Yu F,Yao H,Zhu P,et al.Let-7 regulates self renewal and tumori-genicity of breast cancer cells[J].Cell,2007,131 (6):1109-1123.
  • 5Johnson CD,Esquela-Kerscher A,Stefani G,et al.The let-7 microrna represses cell proliferation pathways in human cells[J].Cancer Res,2007,67(16):7713-7722.
  • 6Wang Y,Hu X,Greshock J,et al.Genomic DNA copy-number alterations of the let-7 family in human cancers[J].PLoS One,2012,7(9):e44399.
  • 7Ambros V.Micrornas:Tiny regulators with great potential[J].Cell,2001,107(7):823-826.
  • 8Yu F,Deng H,Yao H,et al.Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells[J].Oncogene,2010,29(29):4194-4204.
  • 9Shimono Y,Zabala M,Cho RW,et al.Downregulation of mirna200c links breast cancer stem cells with normal stem cells[J].Cell,2009,138(3):592-603.
  • 10Iliopoulos D,Lindahl-Allen M,Polytarchou C,et al.Loss of mir200 inhibition of suzl2 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells[J].Mol cell,2010,39(5):761-772.
国际肿瘤学杂志
2014年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部