2013年北京地区手足口病的流行趋势

Prevalent tendency of hand, foot and mouth disease in Beijing during 2013

目的了解2013年北京地区手足口病的流行病学特点,为手足口病的防控工作提供一定的科学依据。方法收集2013年北京地区手足口病患者的咽拭子和（或）便标本,应用实时荧光逆转录PCR（RT-PCR）法进行病原体的检测,同时收集和整理相关临床资料。结果 2013年北京地区手足口病多见于≤3岁年龄组儿童（占88.84%）;5～8月份为手足口病发病高峰;非EV71非Cox A16肠道病毒为手足口病的主要病原体（占43.72%）;6例EV71和3例Cox A16分别属于C4a和B1b亚型,并存在多个传播链。结论 2013年北京地区手足口病高峰时间延长,非EV71非Cox A16型肠道病毒成为引起手足口病的主要病原体。

Objectives To investigate the epidemic characteristics of hand, foot and mouth diseases（HFMD） in Beijing during 2013, and provide scientific basis for the prevention and control of HFMD. Methods Pharyngeal swab and/or stool samples of patients clinically diagnosed as HFMD developed in Beijing during 2013 were collected. The pathogen were detected by real-time fluorescence reverse transcription PCR（RT-PCR） method, while the clinical data of the patients were collected and sorted at the same time. Results HFMD was mainly（88.84%） occurred in children under 3 years old in Beijing during 2013. And HFMD occured mainly from May to August. Non-enterovirus 71（EV71） and non-Coxsackievirus A16（Cox A16） enterovirus was the main causative pathogens, with a positive rate of 43.72%. There were 6 strains of EV71 and 3 strains of Cox A16 belonged to C4 a and B1 b subtype, respectively, with several transmission chains. Conclusions In Beijing during 2013, the peak duration of HFMD was one month longer than before, non-EV71 and non-Cox A16 enterovirus became the main causative pathogen.