TCT和HR-HPVDNA检测对宫颈病变筛查的价值

The value of TCT and HPV-DNA detection in screening of cervical lesions

目的:探讨液基薄层细胞学检测(TCT)和高危型人乳头瘤状病毒DNA(HR-HPV DNA)检测对宫颈病变筛查的价值,为政府制定疫苗的预防政策提供理论依据。方法:选取在我院就诊或体检的妇女243例,均行TCT、HRHPV DNA检测,分析其检测结果。结果:TCT+HR-HPV DNA联合检测的特异性、阳性预测值和诊断符合率均明显高于HR-HPV DNA单项检测,差异具有统计学意义(P<0.05)。结论:TCT和HR-HPV DNA联合检测可提高宫颈病变及早期宫颈癌的诊断水平,降低漏诊率,对宫颈病变的早期筛查具有重要意义。

Objective： To investigate the value of thinprep cytology test （TCT） and high-risk human papilloma virus DNA （HR-HPV DNA） detection in the screening of cervical lesions so as to provide a theoretical basis for the government to formulate the vaccine prevention policy. Methods： Two hundred and forty-three women diagnosed or examined in our hospital were selected, to whom TCT and the detection of HR-HPV DNA were performed and their results were analyzed. Results： The specificity, positive predictive value and diagnosis rate were obviously higher by the combined detection of TCT and HR-HPV DNA than by single detection of HR-HPV DNA and their differences had statistical significance （P〈0.05）. Conclusion： The combined detection of TCT and HR-HPV DNA can improve the diagnosis level of cervical lesions and early cervical cancer, reduce the rate of misdiagnosis and has important significance for the early screening of cervical lesions.